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REVIEW article

Front. Microbiol.
Sec. Food Microbiology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1492179

Harnessing lactic acid bacteria for nicotinamide mononucleotide biosynthesis: a review of strategies and future directions

Provisionally accepted
Linghui Kong Linghui Kong 1*Xinyu Li Xinyu Li 1Taiyu Liu Taiyu Liu 2Qingshou Yao Qingshou Yao 1Jiayang Qin Jiayang Qin 1
  • 1 School of Pharmacy, Binzhou Medical University, Yantai, Shandong Province, China
  • 2 Shanghai Advanced Research Institute, Chinese Academy of Sciences (CAS), Pudong, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Nicotinamide mononucleotide (NMN), one of the crucial precursors of nicotinamide adenine dinucleotide, has garnered considerable interest for its pharmacological and anti-aging effects, conferring potential health and economic benefits for humans. Lactic acid bacteria (LAB) is one of the most important probiotics, which is commonly used in the dairy industry. Due to its probiotic properties, present an attractive platform for food-grade NMN production. LAB has also been extensively utilized to enhance the functional properties of pharmaceuticals and cosmetics, making them promising candidates for large-scale up synthesis of NMN. This review provides an in-depth analysis of various metabolic engineering strategies, including enzyme optimization, pathway rewiring, and fermentation process enhancements, to increase NMN yields in LAB. It explores both CRISPR/Cas9 and traditional methods to manipulate key biosynthetic pathways. In particular, this study discussed future research directions, emphasizing the application of synthetic biology, systems biology, and AI-driven optimization to further enhance NMN production. It provides invaluable insights into developing scalable and industrially relevant processes for NMN production to meet the growing market demand.

    Keywords: Lactic acid bacteria, Nicotinamide Mononucleotide, biosynthesis, Metabolic Engineering, Microbial Fermentation

    Received: 06 Sep 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Kong, Li, Liu, Yao and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Linghui Kong, School of Pharmacy, Binzhou Medical University, Yantai, 264003, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.