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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1491039
This article is part of the Research Topic Lactic Acid Bacteria and their Bioactive Compounds: Key Regulators of Gut Microbiota and Immune Function View all 7 articles

Oral administration of Limosilactobacillus ingluviei C37 inhibits Campylobacter jejuni colonization in chicks

Provisionally accepted
Aito Murakami Aito Murakami 1Ayako Watanabe-Yanai Ayako Watanabe-Yanai 2Taketoshi Iwata Taketoshi Iwata 2Fu Namai Fu Namai 3,4Takashi Sato Takashi Sato 5Tadashi Fujii Tadashi Fujii 6,7,8Takumi Tochio Takumi Tochio 6,7,8Sutisa Khempaka Sutisa Khempaka 9Takeshi Shimosato Takeshi Shimosato 10,5*
  • 1 Graduate School of Medicine, Science and Technology, Shinshu University, Nagano, Nagano, Japan
  • 2 National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
  • 3 Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
  • 4 Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
  • 5 Institute for Biomedical Sciences, Shinshu University, Nagano, Nagano, Japan
  • 6 Department of Gastroenterology and Hepatology, Fujita Health University, Aichi, Japan
  • 7 Department of Medical Research on Prebiotics and Probiotics, Fujita Health University, Aichi, Japan
  • 8 BIOSIS Lab. Co., Ltd., Aichi, Japan
  • 9 School of Animal Technology and Innovation, Suranaree University of Technology, Nakhon Ratchasima, Thailand
  • 10 Institute for Aqua Regeneration, Shinshu University, Nagano, Nagano, Japan

The final, formatted version of the article will be published soon.

    As the global population continues to grow, so too does the demand for poultry meat. However, the concurrent increase in the prevalence of drug-resistant bacteria has stimulated interest in the search for alternatives to antibiotics in poultry and livestock agriculture. One potential strategy is the use of probiotics. In this study, we showed that prophylactic oral administration of Limosilactobacillus ingluviei C37 (LIC37) reduced Campylobacter jejuni colonization of the cecum in cage-raised chicks, without causing significant changes in the overall diversity of gut bacteria.Further, the abundance of Blautia, another genus of probiotic bacteria, increased in the gastrointestinal tract following ingestion of LIC37 by chicks. These findings suggest that LIC37 could potentially be used as a novel probiotic agent against C. jejuni in livestock production.

    Keywords: Limosilactobacillus ingluviei C37, Campylobacter jejuni, Gut Microbiota, chicken, Probiotics

    Received: 04 Sep 2024; Accepted: 07 Nov 2024.

    Copyright: © 2024 Murakami, Watanabe-Yanai, Iwata, Namai, Sato, Fujii, Tochio, Khempaka and Shimosato. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Takeshi Shimosato, Institute for Biomedical Sciences, Shinshu University, Nagano, Nagano, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.