Skip to main content

ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1487393
This article is part of the Research Topic Hot Topics 2023: Systematic approaches to Respiratory Diseases: Pathology and Therapeutics View all 5 articles

Exploring the potential role of microbiota and metabolites in acute exacerbation of chronic obstructive pulmonary disease

Provisionally accepted
Yanmin Shi Yanmin Shi 1Jianya Yang Jianya Yang 1,2Tao Tian Tao Tian 1,2Suyun Li Suyun Li 1,2,3*Yang Xie Yang Xie 1,2,3*
  • 1 First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
  • 2 National Regional Chinese Medicine (Lung disease) Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China
  • 3 Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co-constructed by Henan province & Education Ministry, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    The acute exacerbation of chronic obstructive pulmonary disease seriously affects the respiratory system function and quality of life of patients. This study employed 16S rRNA sequencing and metabolomics techniques to analyze the respiratory microbiota and serum metabolites of COPD and AECOPD patients. The results showed that the microbial diversity in the respiratory tract of AECOPD patients was significantly lower than that of COPD patients, and the relative abundance of Bacteroidetes, Prevotella and Neisseria in the respiratory tract of AECOPD patients was significantly lower than that of COPD patients. However, the relative abundance of Haemophilus_D, Veillonella_A and Pseudomonas_E, in AECOPD patients was significantly higher than that of COPD patients, and the ability of respiratory microbiota in AECOPD patients to participate in alanine metabolism was significantly lower than that of COPD patients. Metabolome results further revealed that the serum alanine levels in AECOPD patients were significantly lower than those in COPD patients, and these differential metabolites were mainly involved in linoleic acid metabolism, protein digestion and absorption and regulation of lipolysis in adipocytes. In summary, the structural characteristics of respiratory microbiota in COPD and AECOPD patients are different from those in healthy populations, and their microbiota diversity decreases and microbial community structure and function will also undergo changes when acute exacerbations occur. In addition, the predicted microbial community function and metabolomics results indicate that the onset of AECOPD is mainly related to energy and amino acid metabolism disorders, especially alanine metabolism.

    Keywords: COPD, AECOPD, Respiratory microbiota, metabolite, Maker

    Received: 28 Aug 2024; Accepted: 02 Oct 2024.

    Copyright: © 2024 Shi, Yang, Tian, Li and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Suyun Li, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
    Yang Xie, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.