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REVIEW article

Front. Microbiol.
Sec. Virology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1483022

Multiple functions of the herpesvirus UL14 gene product in viral infection

Provisionally accepted
Jieyu Wan Jieyu Wan 1,2,3,4,5Mingshu Wang Mingshu Wang 1,2,3,4,5*Anchun Cheng Anchun Cheng 1,2,3,4,5*Wei Zhang Wei Zhang 6Qiao Yang Qiao Yang 1,2,3,4,5Bin Tian Bin Tian 1,2,3,4,5Xumin Ou Xumin Ou 1,2,3,4,5Di Sun Di Sun 1,2,3,4,5Yu He Yu He 1,2,3,4,5Xinxin Zhao Xinxin Zhao 1,2,3,4,5Ying Wu Ying Wu 1,2,3,4,5Shaqiu Zhang Shaqiu Zhang 1,2,3,4,5Juan Huang Juan Huang 1,2,3,4,5Zhen Wu Zhen Wu 1,2,3,4,5Yanling Yu Yanling Yu 1,2,3Ling Zhang Ling Zhang 1,2,3Dekang Zhu Dekang Zhu 2,3,4,5Mafeng Liu Mafeng Liu 1,2,3,4,5Shun Chen Shun Chen 1,2,3,4,5Renyong Jia Renyong Jia 1,2,3,4,5
  • 1 Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University,, Chengdu, China
  • 2 Key Laboratory of Animal Disease and Human Health of Sichuan Province,, Chengdu, China
  • 3 International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, China
  • 4 Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, China
  • 5 Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
  • 6 Sinopharm Yangzhou Vac Biological Engineering Co. LtD, Yangzhou, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Herpesviruses are a family of double-stranded DNA viruses with a tegument structure and a genome composed of a single sequence and terminal repeat sequences. The herpesvirus UL14 gene encodes the protein UL14 (pUL14), which has various subcellular localizations, plays critical roles in regulating immediate-early gene transcription and expression, influences the intracellular localization patterns of a number of proteins belonging to the capsid and the DNA packaging machinery, participates in secondary envelopment, and influences viral particle release. Additionally, pUL14 has roles in maintaining cellular homeostasis and preventing apoptosis. This review discusses how pUL14 participates in the life cycle of herpesviruses and provides new ideas for further research on pUL14 function in viral infection.

    Keywords: herpesvirus, pUL14, Tegument proteins, viral replication, viral infection

    Received: 19 Aug 2024; Accepted: 08 Oct 2024.

    Copyright: © 2024 Wan, Wang, Cheng, Zhang, Yang, Tian, Ou, Sun, He, Zhao, Wu, Zhang, Huang, Wu, Yu, Zhang, Zhu, Liu, Chen and Jia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Mingshu Wang, Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University,, Chengdu, China
    Anchun Cheng, Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University,, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.