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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1481582

Endoscopic surgery affects the gut microbiota and its metabolism in breast cancer patients

Provisionally accepted
Jingtai Li Jingtai Li 1Fangfang Gao Fangfang Gao 1Runwei Li Runwei Li 2Zhilin Chen Zhilin Chen 1Guoping Chen Guoping Chen 1Pingming Fan Pingming Fan 1Guankui Du Guankui Du 2*
  • 1 First Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
  • 2 Hainan Medical University, Haikou, China

The final, formatted version of the article will be published soon.

    Background: Despite the advantages of endoscopic surgery in reducing trauma and enhancing recovery for breast cancer patients, its impact on gut microbiota, which is crucial for health and estrogen metabolism, remains unclear. Further investigation is necessary to fully understand this impact and its implications.Between June and December 2022, fecal samples were collected from 20 patients who underwent endoscopic surgery. The gut microbiota composition was determined using 16S rRNA sequencing, while the metabolites were analyzed through liquid chromatography-tandem mass spectrometry (LC-MS/MS).Bioinformatics and statistical analyses were employed to identify significant alterations in microbial taxa abundance and to assess intergroup differences. These analyses included t-tests for pairwise comparisons, one-way ANOVA for multiple group comparisons, and chi-square tests for categorical data analysis.Results: Endoscopic surgery in breast cancer patients subtly changed gut microbiota diversity and composition. Post-surgery, there was a reduction in Lachnospiraceae, Monoglobaceae and Firmicutes to Bacteroides ratios. Shifts in metabolites were also observed, The changed metabolites impacted pathways such as primary bile biosynthesis and Ascorbate and aldarate metabolism, with PE(PGD1/18:1(9Z)) identified as a key differential metabolite that increased post-surgery. Azasetron, Tyramine glucuronide, DL-Dopa, Phthalide, Acetophenazine, Aciclovir, Creatinine bicarbonate, and 4-Oxo-L-proline being associated with distinct bacterial taxa.Breast cancer patients undergoing endoscopic surgery experience a shift in their gut microbiota and metabolic profiles. Therefore, postoperative management, with a particular focus on the adjustment of the gut microbiota, is crucial for enhancing patient recovery and health outcomes.

    Keywords: breast cancer, Endoscopic Surgery, Gut Microbiota, Metabolites, 16S rRNA

    Received: 19 Aug 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Li, Gao, Li, Chen, Chen, Fan and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guankui Du, Hainan Medical University, Haikou, China

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