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REVIEW article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1481496

Microscopic Messengers: Microbiota Derived Bacterial Extracellular Vesicles in Inflammatory Bowel Disease

Provisionally accepted
Muhammad Zubair Muhammad Zubair 1,2,3Fatma A. Aboulnazar Fatma A. Aboulnazar 2,3,4Ali Dawood Ali Dawood 5Jingyun Pan Jingyun Pan 6*XuWen Zheng XuWen Zheng 7Tao Chen Tao Chen 8*Pengjun Liu Pengjun Liu 8*Fei Mao Fei Mao 9Yongmin Yan Yongmin Yan 2*Ying Chu Ying Chu 10,11*
  • 1 Changzhou Wujin People's Hospital, Changning, China
  • 2 Department of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, 213017 Changzhou, China., Changzhou, China
  • 3 Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, China., Changzhou, China
  • 4 Faculty of Applied Health sciences technology, Pharos University, Alexandria, Egypt., Alexandria, Egypt
  • 5 Medicine and Infectious Diseases Department, Faculty of Veterinary Medicine, University of Sadat City 32897, Egypt., Sadat, Egypt
  • 6 Department of Traditional Chinese Medicine, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, China., Changzhou, China
  • 7 Department of Emergency, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, China., Changzhou, China
  • 8 Department of Gastroenterology, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, China., Changzhou, China
  • 9 Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu, P.R. China., Zhenjiang, China
  • 10 Wujin Clinical College, Xuzhou Medical University, Changzhou 213017, China, Changzhou, China
  • 11 Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China, Xuzhou, China

The final, formatted version of the article will be published soon.

    Inflammatory Bowel Disease (IBD) is a persistent and complex condition accomplished by inflammation of the gastrointestinal system, encompassing Crohn's disease (CD) and Ulcerative colitis (UC). This condition is triggered by the combination of genetic predispositions, environmental triggers, and dysregulated immunological responses, building complications in diagnosing and treating the condition. The latest developments in gastroenterology have revealed the critical significance of the gut microbiota in the pathogenesis of IBD. Extracellular vesicles (EVs) are a type of microbial component that potentially regulate intestinal inflammation. The impact of microbiota-derived bacterial EVs (bEVs) on intestinal inflammation is mediated through several methods. They can intensify inflammation or stimulate defensive responses by delivering immunomodulatory cargo. Improved comprehension could enhance inventive diagnostic and treatment strategies for IBD. This study seeks to explore the deep connection between microbiota-derived bEVs and the complex nature of IBD. It provides a thorough analysis of the formation, composition, mechanisms of action, diagnostic possibilities, therapeutic implications, and future prospects of these microbiota-derived bEVs.

    Keywords: Dysbiosis1, Extracellular vesicles2, IBD3, Immune regulation4, microbiota5

    Received: 16 Aug 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Zubair, Aboulnazar, Dawood, Pan, Zheng, Chen, Liu, Mao, Yan and Chu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jingyun Pan, Department of Traditional Chinese Medicine, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, China., Changzhou, China
    Tao Chen, Department of Gastroenterology, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, China., Changzhou, China
    Pengjun Liu, Department of Gastroenterology, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, China., Changzhou, China
    Yongmin Yan, Department of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, 213017 Changzhou, China., Changzhou, China
    Ying Chu, Wujin Clinical College, Xuzhou Medical University, Changzhou 213017, China, Changzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.