Skip to main content

ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1480446

High-fat diet promotes gestational diabetes mellitus through modulating gut microbiota and bile acids metabolism

Provisionally accepted
Pengfei Qiao Pengfei Qiao 1*Xuefei Zhou Xuefei Zhou 2*Xianqi Jiang Xianqi Jiang 3*Hao Chen Hao Chen 3*Yuanliang Li Yuanliang Li 3*Xiao Xiong Xiao Xiong 3*Yan Tang Yan Tang 3*Haogang Zhang Haogang Zhang 3*
  • 1 Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
  • 2 Harbin Red Cross Hospital, Harbin, Jilin Province, China
  • 3 The Second Affiliated Hospital of Harbin Medical University, Harbin, China

The final, formatted version of the article will be published soon.

    Gestational diabetes mellitus (GDM) is a condition characterized by glucose intolerance during pregnancy, estimated to affect approximately 20% of the whole pregnancies and is increasing in prevalence globally. However, there is still a big gap in knowledge about the association between gut microbiota associated metabolism alterations and GDM development. Our data indicated that high fat diet (HFD) was linked with higher prevalence of GDM, and HFD was positively associated with poor prognosis in GDM patients. Moreover, compared with normal diet (ND) group, GDM patients from HFD group performed a loss of gut microbiota diversity and enrichment of Alistipes onderdonkii, Lachnospiraceae bacterium 1_7_58FAA, Clostridium aspaaragiforme while ruduction of Akkermansiaceae, Paraprevotell xylaniphila, Prevotella copri. Additionally, HFD aggravated GDM in mice and gut microbiota depletion by antibiotics crippled the effect of excess fat intake. BAs profile altered in HFD GDM patients and mice models. Fecal microbiota transplantation (FMT) further confirmed that gut microbiota contributed to bile

    Keywords: high fat diet, gestational diabetes mellitus, Gut Microbiota, Bile acids metabolism, FXR pathway

    Received: 15 Aug 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Qiao, Zhou, Jiang, Chen, Li, Xiong, Tang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Pengfei Qiao, Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Xuefei Zhou, Harbin Red Cross Hospital, Harbin, Jilin Province, China
    Xianqi Jiang, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Hao Chen, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Yuanliang Li, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Xiao Xiong, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Yan Tang, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Haogang Zhang, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.