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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1479779
This article is part of the Research Topic Bifidobacteria: Exploring the Roles of These Microbiome Guardians and Their Effects on Human Health View all 5 articles

Characteristics of the gut microbiota and the effect of Bifidobacterium in very early-onset inflammatory bowel disease patients with IL10RA mutations

Provisionally accepted
Xu Xu Xu Xu 1Yuan Qi Gao Yuan Qi Gao 1Yuan Xiao Yuan Xiao 1Yi Yu Yi Yu 1Jie Bin Huang Jie Bin Huang 1Wen Su Wen Su 1Na Li Na Li 2Chundi Xu Chundi Xu 1*Shenshen Gao Shenshen Gao 3*Xinqiong Wang Xinqiong Wang 1*
  • 1 Department of Pediatrics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  • 2 Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
  • 3 Shanghai Shenkang Hospital Development Center, Shanghai, China

The final, formatted version of the article will be published soon.

    Very early-onset inflammatory bowel disease (VEO-IBD) is a distinct subtype of inflammatory bowel disease (IBD) characterized by onset before the age of 6 years, and patients often exhibit more severe clinical features. Interleukin 10 receptor alpha (IL10RA) is a hotspot mutation in the Chinese population and is associated with a poor prognosis closely linked to the onset of IBD. However, limited knowledge exists regarding how the IL10RA mutation influences the host microbiota and its role in disease development. We employed 16S rRNA sequencing to conduct a comprehensive assessment of microbial changes in different types of IBD and to demonstrate a potential positive effect exerted by Bifidobacterium breve M16V (M16V) through a mouse model. The study demonstrated a significant reduction in the abundance and diversity of the gut microbiota among children with IL10RA mutations compared to those with late-onset pediatric IBD and nonmutated VEO-IBD. Furthermore, the analysis identified genera capable of distinguishing between various types of IBD, with the genus Bifidobacterium emerging as a potential standalone diagnostic indicator. In this study, we employed a database to thoroughly examine the influence of Bifidobacterium in IBD. Furthermore, Bifidobacterium may also be involved in related pathways that influence the progression of IBD, such as the biosynthesis of amino acids and inflammation-related pathways. This study corroborated the efficacy of Bifidobacterium in alleviating intestinal inflammation. The impact of IL10RA mutations on VEO-IBD may be mediated by alterations in microbes. M16V demonstrates efficacy in alleviating colitis and holds promise as a novel microbial therapy.

    Keywords: Bifidobacterium, Dysbacteriosis, Gut Microbiota, IL10RA mutant, very early-onset IBD

    Received: 12 Aug 2024; Accepted: 12 Nov 2024.

    Copyright: © 2024 Xu, Gao, Xiao, Yu, Huang, Su, Li, Xu, Gao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chundi Xu, Department of Pediatrics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    Shenshen Gao, Shanghai Shenkang Hospital Development Center, Shanghai, China
    Xinqiong Wang, Department of Pediatrics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.