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REVIEW article

Front. Microbiol.
Sec. Microbial Symbioses
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1478082

The Potential influence and intervention measures of gut microbiota on sperm：it is time to focus on Testis-Gut microbiota Axis

Provisionally accepted
Wenkang Chen Wenkang Chen 1Hede Zou Hede Zou 1Haoran Xu Haoran Xu 2*Rui Cao Rui Cao 2*Hekun Zhang Hekun Zhang 2*Yapeng Zhang Yapeng Zhang 1*Jiayou Zhao Jiayou Zhao 1*
  • 1 Graduate School of China Academy of Chinese Medical Sciences, Beijing, China
  • 2 Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, China

The final, formatted version of the article will be published soon.

    As the global male infertility rate continues to rise, there is an urgent imperative to investigate the underlying causes of sustained deterioration in sperm quality. The gut microbiota emerges as a pivotal factor in host health regulation, with mounting evidence highlighting its dual influence on semen. This review underscores the interplay between the Testis-Gut microbiota axis and its consequential effects on sperm. Potential mechanisms driving the dual impact of gut microbiota on sperm encompass immune modulation, inflammatory responses mediated by endotoxins, oxidative stress, antioxidant defenses, gut microbiota-derived metabolites, epigenetic modifications, regulatory sex hormone signaling. Interventions such as probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and Traditional natural herbal extracts are hypothesized to rectify dysbiosis, offering avenues to modulate gut microbiota and enhance Spermatogenesis and motility. Future investigations should delve into elucidating the mechanisms and foundational principles governing the interaction between gut microbiota and sperm within the Testis-Gut microbiota Axis.Understanding and modulating the Testis-Gut microbiota Axis may yield novel therapeutic strategies to enhance male fertility and combat the global decline in sperm quality.

    Keywords: Gut Microbiota, Spermatogenesis, Sperm motility ；Testis-Gut microbiota Axis； Dual impact, Mechanism, Intervention measures

    Received: 09 Aug 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Chen, Zou, Xu, Cao, Zhang, Zhang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Haoran Xu, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei Province, China
    Rui Cao, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei Province, China
    Hekun Zhang, Hebei University of Chinese Medicine, Shijiazhuang, 050200, Hebei Province, China
    Yapeng Zhang, Graduate School of China Academy of Chinese Medical Sciences, Beijing, China
    Jiayou Zhao, Graduate School of China Academy of Chinese Medical Sciences, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.