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REVIEW article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1477187

Gut microbiota mediated T cells regulation and autoimmune diseases

Provisionally accepted
Nabeel Khalid Bhutta Nabeel Khalid Bhutta 1Xu Xiujin Xu Xiujin 1*Cuiqin Jian Cuiqin Jian 1*Yifan Wang Yifan Wang 1*Yi Liu Yi Liu 2Jinlyu Sun Jinlyu Sun 3,4,5*Bingnan Han Bingnan Han 1*Ansar Javeed Ansar Javeed 1*Shandong Wu Shandong Wu 2*
  • 1 Zhejiang Sci-Tech University, Hangzhou, China
  • 2 Hangzhou Zheda Dixun Biological Gene Engineering Co., LTD., Hangzhou, P.R. China., Hangzhou, China
  • 3 Department of Allergy, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing 100730, China., Beijing, China
  • 4 National Clinical Research Center for Dermatologic and Immunologic diseases, Beijing 100730, China, Beijing, China
  • 5 Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China, Beijing, China

The final, formatted version of the article will be published soon.

    Gut microbiota regulates the immune system, the development and progression of autoimmune diseases (AIDs) and overall health. Recent studies have played a crucial part in understanding the specific role of different gut bacterial strains and their metabolites in different AIDs. Microbial signatures in AIDs are revealed by advanced sequencing and metabolomics studies. Microbes such as Faecalibacterium prausnitzii, Akkermansia muciniphila, Anaerostipes caccae, Bacteroides sp., Roseburia sp., Blautia sp., Blautia faecis, Clostridium lavalense, Christensenellaceae sp., Coprococcus sp., Firmicutes sp., Ruminococcaceae sp., Lachnospiraceae sp., Megamonas sp., Monoglobus sp., Streptococcus pneumoniae and Bifidobacterium sp. help maintain immune homeostasis; whereas, Prevotella copri, Ruminococcus gnavus, Lactobacillus salivarius, Enterococcus gallinarum, Elizabeth menigoseptica, Collinsella sp., Escherichia sp., Fusobacterium sp., Enterobacter ludwigii, Enterobacteriaceae sp., Proteobacteria, Porphyromonas gingivalis, Porphyromonas nigrescens, Dorea sp., and Clostridium sp. cause immuno-pathogenesis. A complex web of interactions is revealed by understanding the influence of gut microbiota on immune cells and various T cell subsets such as CD4+ T cells, CD8+ T cells, natural killer T cells, γδ T cells, etc. Certain AIDs, including rheumatoid arthritis, diabetes mellitus, atopic asthma, inflammatory bowel disease and non-alcoholic fatty liver disease exhibit a state of dysbiosis, characterized by alterations in microbial diversity and relative abundance of specific taxa. This review summarizes recent developments in understanding the role of certain microbiota composition in specific AIDs, and the factors affecting specific regulatory T cells through certain microbial metabolites and also focuses the potential application. and therapeutic significance of gut microbiota-based interventions as novel adjunctive therapies for AIDs. Further research to determine the precise association of each gut bacterial strain in specific diseases is required.

    Keywords: muciniphila, Anaerostipes caccae, Bacteroides sp., Roseburia sp., Blautia sp., Blautia faecis, Clostridium lavalense, Christensenellaceae sp.

    Received: 07 Aug 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Bhutta, Xiujin, Jian, Wang, Liu, Sun, Han, Javeed and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xu Xiujin, Zhejiang Sci-Tech University, Hangzhou, China
    Cuiqin Jian, Zhejiang Sci-Tech University, Hangzhou, China
    Yifan Wang, Zhejiang Sci-Tech University, Hangzhou, China
    Jinlyu Sun, Department of Allergy, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing 100730, China., Beijing, China
    Bingnan Han, Zhejiang Sci-Tech University, Hangzhou, China
    Ansar Javeed, Zhejiang Sci-Tech University, Hangzhou, China
    Shandong Wu, Hangzhou Zheda Dixun Biological Gene Engineering Co., LTD., Hangzhou, P.R. China., Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.