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REVIEW article

Front. Microbiol.
Sec. Microbial Symbioses
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1476908

Gut Microbiota: A Novel Target for Exercise-Mediated Regulation of NLRP3 Inflammasome Activation

Provisionally accepted
Jun Chen Jun Chen Shaohui Jia Shaohui Jia *Xinxuan Xue Xinxuan Xue *Chenggen Guo Chenggen Guo Kunwei Dong Kunwei Dong *
  • Wuhan Sports University, Wuhan, China

The final, formatted version of the article will be published soon.

    The NOD-like receptor family pyrin domain-containing 3 (NLRP3) is a key pattern recognition receptor in the innate immune system. Its overactivation leads to the production of pro-inflammatory cytokines, such as IL-1β and IL-18, which contribute to the development and progression of various diseases. In recent years, evidence has shown that gut microbiota plays an important role in regulating the activation of NLRP3 inflammasome. Variations in the function and composition of gut microbiota can directly or indirectly influence NLRP3 inflammasome activation by influencing bacterial components and gut microbiota metabolites. Additionally, exercise has been shown to effectively reduce NLRP3 inflammasome overactivation while promoting beneficial changes in gut microbiota. This suggests that gut microbiota may play a key role in mediating the effects of exercise on NLRP3 inflammasome regulation. This review explores the impact of exercise on gut microbiota and NLRP3 inflammasome activation, and examines the mechanisms through which gut microbiota mediates the anti-inflammatory effects of exercise, providing new avenues for research.

    Keywords: NLRP3 inflammasome, Exercise, Gut Microbiota, Inflammation, Immune Regulation

    Received: 07 Aug 2024; Accepted: 13 Dec 2024.

    Copyright: © 2024 Chen, Jia, Xue, Guo and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shaohui Jia, Wuhan Sports University, Wuhan, China
    Xinxuan Xue, Wuhan Sports University, Wuhan, China
    Kunwei Dong, Wuhan Sports University, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.