Skip to main content

ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1467414

Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and its correlation with BMI: a nested cohort study in China

Provisionally accepted
Shilin Zhong Shilin Zhong 1,2,3Bingcai Yang Bingcai Yang 1,2,3Yuzhen Liu Yuzhen Liu 1,2,3Wenkui Dai Wenkui Dai 1,2,3Guanglei Li Guanglei Li 4Juan Yang Juan Yang 1,2,3Ao Yang Ao Yang 1,2,3Ying Wang Ying Wang 1,2,3Min Wang Min Wang 1,2,3Chang Xu Chang Xu 5Yuqing Deng Yuqing Deng 1,2,3*
  • 1 Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China., Shenzhen, China
  • 2 Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen 518036, Guangdong, China., Shenzhen, China
  • 3 Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen 518036, Guangdong, China., Shenzhen, China
  • 4 CheerLand Biological Technology Co., Ltd. Shenzhen, 518000, China, Shenzhen, China
  • 5 Intelligent Hospital Research Academy, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China., Shenzhen, China

The final, formatted version of the article will be published soon.

    Gut microbiota (GM) has been implicated in gestational diabetes mellitus (GDM), yet longitudinal changes across trimesters remain insufficiently explored. This nested cohort study aimed to investigate GM alterations before 24 weeks of gestation and their association with GDM. Ninetythree Chinese participants provided fecal samples during the first and second trimesters. Based on oral glucose tolerance tests, 11 participants were classified as GDM, and 82 as non-diabetic (ND). Using 16S rRNA sequencing, we analyzed both cross-sectional and longitudinal differences in GM structure between those two groups. In the first trimester, GDM group exhibited lower levels of Bacteroides_H and Acetatifactor compared to ND group (P<0.05). In the second trimester, GDM individuals showed increased abundance of Fusobacteriota and Firmicutes_D, and genera including Fusobacterium_A and Fournierella, while Anaerotruncus and others decreased (P ＜ 0.05). Inflammation-associated genera like Gemmiger_A_73129 and Enterocloster increased, while Megamonas decreased in overweight or obese GDM women, which was not identified in normal-weight women. The ratios of relative abundance of genera Streptococcus, Enterocloster, and Collinsella exceeded 1.5 in the GDM group, particularly in overweight or obese individuals. Inflammatory pathways related to African trypanosomiasis and Staphylococcus aureus infection were predicted to be up-regulated in overweight or obese GDM individuals but not in normalweight GDM women. This study suggests that GM of women with GDM undergoes significant alterations between the first and second trimesters, potentially linked to inflammation, with more pronounced changes observed in overweight or obese individuals.

    Keywords: gestational diabetes mellitus, Gut Microbiota, Body Mass Index, Obesity, Inflammation

    Received: 22 Jul 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Zhong, Yang, Liu, Dai, Li, Yang, Yang, Wang, Wang, Xu and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuqing Deng, Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China., Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.