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REVIEW article

Front. Microbiol.
Sec. Virology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1457582

Functions of the UL51 protein during the herpesvirus life cycle

Provisionally accepted
Xiaolan Liu Xiaolan Liu 1,2,3,4,5Mingshu Wang Mingshu Wang 1,2,3,4,5*Anchun Cheng Anchun Cheng 1,2,3,4,5Qiao Yang Qiao Yang 1,2,3,4,5Bin Tian Bin Tian 1,2,3,4,5Xumin Ou Xumin Ou 1,2,3,4,5Di Sun Di Sun 1,2,3,4,5Yu He Yu He 1,2,3,4,5Zhen Wu Zhen Wu 1,2,3,4,5Xinxin Zhao Xinxin Zhao 1,2,3,4,5Ying Wu Ying Wu 1,2,3,4,5Shaqiu Zhang Shaqiu Zhang 1,2,3,4,5Juan Huang Juan Huang 1,2,3,4,5Renyong Jia Renyong Jia 1,2,3,4,5Shun Chen Shun Chen 1,2,3,4,5Mafeng Liu Mafeng Liu 1,2,3,4,5Dekang Zhu Dekang Zhu 1,2,3,4,5
  • 1 Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan Province, China
  • 2 Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan Province, China
  • 3 International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, Sichuan Province, China
  • 4 Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University,, Chengdu, Sichuan Province, China
  • 5 Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    The herpesvirus UL51 protein is a multifunctional tegument protein involved in the regulation of multiple aspects of the viral life cycle. This article reviews the biological characteristics of the UL51 protein and its functions in herpesviruses, including participating in the maintenance of the viral assembly complex (cVAC) during viral assembly, affecting the production of mature viral particles and promoting primary and secondary envelopment, as well as its positive impact on viral cell-to-cell spread (CCS) through interactions with multiple viral proteins and its key role in the proliferation and pathogenicity of the virus in the later stage of infection. This paper discusses how the UL51 protein participates in the life cycle of herpesviruses and provides new ideas for further research on UL51 protein function.

    Keywords: herpesvirus, UL51, Secondary envelopment, Viral life cycle, pathogenicity 1 Introduction

    Received: 01 Jul 2024; Accepted: 07 Aug 2024.

    Copyright: © 2024 Liu, Wang, Cheng, Yang, Tian, Ou, Sun, He, Wu, Zhao, Wu, Zhang, Huang, Jia, Chen, Liu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mingshu Wang, Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.