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SYSTEMATIC REVIEW article

Front. Microbiol.
Sec. Food Microbiology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1455540
This article is part of the Research Topic Probiotics for Global Health: Advances, Applications and Challenges View all 18 articles

Biological function of D-tryptophan: A bibliometric analysis and review

Provisionally accepted
Fei Wang Fei Wang 1Runyu Du Runyu Du 2*Yunxiao Shang Yunxiao Shang 1*
  • 1 Department of Pediatrics, ShengJing Hospital of China Medical University, Shenyang, China
  • 2 Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

The final, formatted version of the article will be published soon.

    D-Tryptophan is recognised for its unique physiological properties. In this study, we aimed to explore the dynamic trends and emerging topics in D-tryptophan research to offer fresh perspectives for future studies. Employing bibliometric analysis, we examined the literature on D-tryptophan indexed in the Web of Science Core Collection from January 1987 to December 2023. The "Bibliometrix" R package and CiteSpace were utilised for data processing. Analyses of 865 publications revealed 2209 keywords, 4068 authors, 2094 institutions, and contributors from 302 regions. The USA was at the forefront of publications concerning D-tryptophan, but the European Journal of Pharmacology, Journal of Biological Chemistry, and Journal of Medicinal Chemistry were notable for their contributions, co-citations, and impact, respectively. This literature review reveals that since 1987, studies have developed from a focus on D-tryptophan metabolism to the exploration of its functions in organic and medicinal chemistry and food science. Recent findings highlight the potential of Dtryptophan as a non-nutritional sweetener and food preservative as well as its role in inhibiting the growth of bacterial biofilms. Additionally, its immunomodulatory properties are being investigated in relation to allergic diseases. Furthermore, D-tryptophan plays a role in the therapy of atherosclerosis, osteoporosis, tuberculosis, and cancer. The results of bibliometric analysis highlight that future research should focus on the biological functions of D-tryptophan as a food preservative and its use in immunomodulation and drug development, providing strong guidance for future research.

    Keywords: D-tryptophan1, Bibliometric Analysis2, D-amino acids3, biological function4, literature review5

    Received: 27 Jun 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Wang, Du and Shang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Runyu Du, Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China
    Yunxiao Shang, Department of Pediatrics, ShengJing Hospital of China Medical University, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.