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PERSPECTIVE article

Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1453998
This article is part of the Research Topic Advancing Strategies to Combat Protozoan Diseases: From Drug Resistance to Innovative Treatments View all articles

Oleuropein mediated autophagy begets antimalarial drug resistance

Provisionally accepted
Prakriti Sharma Prakriti Sharma 1Neil R. Chaudhary Neil R. Chaudhary 1Sonia Devi Sonia Devi 1NIKUNJ U. TANDEL NIKUNJ U. TANDEL 2*RAJEEV K. TYAGI RAJEEV K. TYAGI 1*
  • 1 Institute of Microbial Technology (CSIR), Chandigarh, India
  • 2 Institute of Science, Nirma University, Ahmedabad, Gujarat, India

The final, formatted version of the article will be published soon.

    Drug resistance in Plasmodium falciparum presents a formidable challenge to the humanity.And, unavailability of an effective vaccine worsens the situation further. Autophagy is one of the mechanisms employed by parasite to evade drug pressure to survive. Autophagy induced by the P. falciparum in response to the oleuropein pressure may answer many questions related to the parasite survival as well as evolving drug tolerance. The survival/autophagy axis could be an important avenue to explore in order to address certain questions related to the evolution of drug resistance. In addition, humanized mouse model of P. falciparum infection could serve as an important preclinical tool to investigate the oleuropein-induced autophagy, potentially helping to dissect the mechanisms underlying the development of antimalarial drug resistance.

    Keywords: Malaria, Autophagy, P. falciparum, drug-resistance, oleuropein, Humanized mouse model Malaria, Humanized mouse model

    Received: 24 Jun 2024; Accepted: 02 Aug 2024.

    Copyright: © 2024 Sharma, Chaudhary, Devi, TANDEL and TYAGI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    NIKUNJ U. TANDEL, Institute of Science, Nirma University, Ahmedabad, Gujarat, India
    RAJEEV K. TYAGI, Institute of Microbial Technology (CSIR), Chandigarh, India

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