Hao Deng
Hongwei Cao
Yanjin Wang
Hua-Ji Qiu
*
Su Li
*The final, formatted version of the article will be published soon.
REVIEW article
Front. Microbiol.
Sec. Virology
Volume 15 - 2024 |
doi: 10.3389/fmicb.2024.1450060
Viral replication organelles: the highly complex and programmed replication machinery
Provisionally accepted- Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
Virus infections usually induce the rearrangement of cellular cytoskeletal proteins and organelle membrane structures, thus creating independent compartments (termed replication organelles (ROs)) to facilitate viral genome replication. Within the ROs, viral replicases, including polymerases, helicases, and ligases, play functional roles during viral replication. These viral replicases are pivotal in the virus life cycle, and numerous studies have demonstrated that the viral replicases could be the potential targets for drugs development. Here, we summarize primarily the key replicases within viral ROs and emphasize the advancements of antiviral drugs targeting crucial viral replicases, providing novel insights into the future development of antiviral strategies.
Keywords: viral replication organelles, Viral helicase, DNA sliding clamp, Viral DNA ligase, Viral polymerase, Antiviral drugs
Received: 16 Jun 2024; Accepted: 15 Jul 2024.
Copyright: © 2024 Deng, Cao, Wang, Li, Dai, Li, Qiu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hua-Ji Qiu, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
Su Li, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
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