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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Systems Microbiology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1449935

Causal Relationship between the Gut Microbiota, Immune Cells, a nd Coronary Heart Disease: A Mediated Mendelian Randomizatio n Analysis

Provisionally accepted
Feifei Yang Feifei Yang 1*Hui Song Hui Song 1Weizhi Tang Weizhi Tang 1Lingyun Liu Lingyun Liu 1*Ziyi Zhu Ziyi Zhu 1*Bin Ouyang Bin Ouyang 1*Liwen Zhang Liwen Zhang 1*Guixin He Guixin He 2*Weibin Qin Weibin Qin 2*
  • 1 Guangxi University of Chinese Medicine, Nanning, China
  • 2 The First Affiliated Hospital of Guangxi University of Chinese Medicine, 530000 Nanning, Guangxi, China, Nanning, China

The final, formatted version of the article will be published soon.

    Background: Recent studies have shown that gut microbiota (GM), immune cells, and coron ary heart disease (CHD) are closely related, but the causal nature is largely unknown. This s tudy aimed to investigate this causal relationship and to reveal the effect of GM, immune ce lls on the risk of developing CHD using mediated Mendelian randomization (MR) analysis.Methods: Firstly, we looked for the data related to GM, immune cells, and CHD through p ublished genome-wide association studies (GWAS), filtered the SNPs (single nucleotide polym orphisms) related to GM and immune cells, and then performed the first MR analysis to get the disease-associated intestinal bacteria and disease-associated immune cells. Then, three M R analyses were performed: disease-associated GM to disease-associated immune cells, disease -associated immune cells to disease, and disease-associated GM to disease. Each MR analysis was performed using inverse variance weighting (IVW), MR-Egger regression, weighted med ian, weighted models, and simple models.Results: 6 GM and 25 immune cells were associated with CHD. P < 0.05 and OR > 1 for the IVW method in the MR analysis of g__Desulfovibrio.s__Desulfovibrio_piger to EM DN (CD4-CD8-) %T cell, P < 0.05 and OR < 1 for the IVW method in the MR analysis of E M DN (CD4-CD8-) %T cell to CHD, and P < 0.05 and OR < 1 for the IVW method in t he MR analysis of g__Desulfovibrio.s__Desulfovibrio_piger to CHD.An increase in the amount of g__Desulfovibrio.s__Desulfovibrio_piger leads to a n increase in the amount of EM DN (CD4-CD8-) %T cell and an increase in the amount o f EM DN (CD4-CD8-) %T cell reduces the risk of developing CHD. Our study provides so me reference for reducing the incidence of coronary heart disease by regulating GM and im mune cells.

    Keywords: Gut Microbiota, immune cells, coronary heart disease, Mendelian randomizati on, genome-wide association studies

    Received: 16 Jun 2024; Accepted: 16 Jul 2024.

    Copyright: © 2024 Yang, Song, Tang, Liu, Zhu, Ouyang, Zhang, He and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Feifei Yang, Guangxi University of Chinese Medicine, Nanning, China
    Lingyun Liu, Guangxi University of Chinese Medicine, Nanning, China
    Ziyi Zhu, Guangxi University of Chinese Medicine, Nanning, China
    Bin Ouyang, Guangxi University of Chinese Medicine, Nanning, China
    Liwen Zhang, Guangxi University of Chinese Medicine, Nanning, China
    Guixin He, The First Affiliated Hospital of Guangxi University of Chinese Medicine, 530000 Nanning, Guangxi, China, Nanning, China
    Weibin Qin, The First Affiliated Hospital of Guangxi University of Chinese Medicine, 530000 Nanning, Guangxi, China, Nanning, China

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