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PERSPECTIVE article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1449133
This article is part of the Research Topic Fecal Microbiota Transplants: challenges in translating microbiome research to clinical applications View all 14 articles

Perspective: On the future of fecal microbiota transplantation

Provisionally accepted
Olaf F. Larsen Olaf F. Larsen 1,2*Robert Brummer Robert Brummer 3
  • 1 VU Amsterdam, Amsterdam, Netherlands
  • 2 Athena Institute, Faculty of Science, VU Amsterdam, Amsterdam, Netherlands
  • 3 Nutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Örebro, Sweden

The final, formatted version of the article will be published soon.

    Fecal Microbiota Transplantation (FMT) has shown to possess impressive potential benefit for a wide range of clinical indications. Due to its inherent safety issues and efficacy constraints, the use of personalized FMT analogues could be a promising avenue. The development of such analogues will require a detailed understanding of their functionality, encompassing not only microbe-host interactions of the microbial taxa that are involved, but also of the ecological dimensions of the analogues and an overview of the gastrointestinal sites where these relevant microbial interactions take place. Moreover, characterization of taxa that have been lost due to diminished exposure to beneficial microbes, as a consequence of Western lifestyle, may lead to creation of future FMT analogues with the capacity to restore functionalities that we have lost.

    Keywords: fecal microbiota transplantation, Gut Microbiota, Probiotics, personalized, analogues, One Health

    Received: 14 Jun 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Larsen and Brummer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Olaf F. Larsen, VU Amsterdam, Amsterdam, Netherlands

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.