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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Systems Microbiology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1447735

Rosa Roxburghii Fermented Juice Mitigates LPS-Induced Acute Lung Injury by Modulation of Intestinal Flora and Metabolites

Provisionally accepted
Zhiyu Chen Zhiyu Chen Shuo Zhang Shuo Zhang Xiaodong Sun Xiaodong Sun Duo Meng Duo Meng Chencen Lai Chencen Lai Min Zhang Min Zhang Pengjiao Wang Pengjiao Wang Xuncai Huang Xuncai Huang Xiuli Gao Xiuli Gao *
  • Guizhou Medical University, Guiyang, China

The final, formatted version of the article will be published soon.

    Acute lung injury represents a formidable challenge in pulmonary pathology, characterized by high mortality and morbidity rates, compounded by the lack of effective pharmacotherapeutic options. Rosa roxburghii Tratt, an exceptionally unique fruit cultivated in the lush regions of southwestern China, is highly esteemed for its rich nutritional content and diverse functional properties. Fermentation, a superior method of food preservation, has the potential to significantly enhance the nutritional value, flavor, and shelf life of Rosa roxburghii Tratt. This study demonstrated that RRFJ modulates gut microbiota and metabolites, increases short-chain fatty acid levels in the intestines, and consequently reduces pulmonary tissue injury, inflammation, and oxidative stress in murine models. Therefore, the findings from this study highlight the potential of RRFJ as a critical scientific basis for its role as a functional dietary adjunct in the management of acute lung injury.

    Keywords: Rosa Roxburghii Fermented Juice, Metabolomics, intestinal flora, Rosa roxburghii, Rosa roxburghii tratt

    Received: 13 Jun 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Chen, Zhang, Sun, Meng, Lai, Zhang, Wang, Huang and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiuli Gao, Guizhou Medical University, Guiyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.