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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1446283
This article is part of the Research Topic Exploring the Depths: Marine-Derived Antimicrobials as New Frontiers in Combating Antimicrobial Resistance View all 3 articles

Anti-Agrobacterium tumefactions sesquiterpene derivatives from the marine-derived fungus Trichoderma effusum

Provisionally accepted
Yunfeng Liu Yunfeng Liu 1*Lu Qi Lu Qi 2*MInghui Xu MInghui Xu 2*Wanyun Li Wanyun Li 2*Na Liu Na Liu 1*Xueli He Xueli He 2Yuxing Zhang Yuxing Zhang 1*
  • 1 Hebei Agricultural University, Baoding, China
  • 2 Hebei University, Baoding, Hebei Province, China

The final, formatted version of the article will be published soon.

    Agrobacterium tumefaciens can harm various fruit trees, leading to significant economic losses in agricultural production. It is urgent to develop new pesticides to effectively treat this bacterial disease. In this study, four new sesquiterpene derivatives, trichoderenes A-D (1-4), along with six known compounds (5-10), were obtained from the marine-derived fungus Trichoderma effusum. The structures of 1-4 were elucidated by extensive spectroscopic analyses, and the calculated ECD, ORD, and NMR methods. Structurally, the hydrogen bond formed between the 1-OH group and the methoxy group, enabled 1 to adopt a structure resembling that of resorcylic acid lactones, thereby producing the ECD cotton effect. Compound 3 represents the first example of C12 nor-sesquiterpene skeleton. Compounds 1-10 were tested for their antimicrobial activity against A. tumefactions. Among them, compounds 1-3 and 8-10 exhibited inhibitory activity against A. tumefactions with MIC values of 3.

    Keywords: Marine-derived fungus, Trichoderma effusum, Sesquiterpene, Agrobacterium tumefaciens, Bioactivity

    Received: 11 Jun 2024; Accepted: 23 Jul 2024.

    Copyright: © 2024 Liu, Qi, Xu, Li, Liu, He and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yunfeng Liu, Hebei Agricultural University, Baoding, China
    Lu Qi, Hebei University, Baoding, Hebei Province, China
    MInghui Xu, Hebei University, Baoding, Hebei Province, China
    Wanyun Li, Hebei University, Baoding, Hebei Province, China
    Na Liu, Hebei Agricultural University, Baoding, China
    Yuxing Zhang, Hebei Agricultural University, Baoding, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.