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SYSTEMATIC REVIEW article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1440241

The association between the gut microbiota metabolite trimethylamine Noxide and heart failure

Provisionally accepted
Zharkyn Jarmukhanov Zharkyn Jarmukhanov 1*Nurislam Mukhanbetzhanov Nurislam Mukhanbetzhanov 1Samat Kozhakhmetov Samat Kozhakhmetov 1Madiyar Nurgaziyev Madiyar Nurgaziyev 1Aliya Sailybayeva Aliya Sailybayeva 2Makhabbat Bekbossynova Makhabbat Bekbossynova 2Almagul Kushugulova Almagul Kushugulova 1
  • 1 Laboratory of Microbiome, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan
  • 2 CF “University Medical Center,” Heart center, Astana, Kazakhstan

The final, formatted version of the article will be published soon.

    The purpose of this systematic review is to develop the concept of the relationship of the gut microbiota metabolite, trimethylamine N-oxide and heart failure. Considering the critical impact that TMAO has on cardiovascular health, the results of our study show that high levels of TMAO are accompanied by atherosclerosis, endothelial dysfunction, and subsequent cardiovascular diseases and can further aggravate heart failure. Our research is a systematic search and meta-analysis of peer-reviewed published papers from 2013 to 2024 adult patients with heart failure and healthy controls. In summary, the current review compiles evidence of the relationship between TMAO level with several cardiovascular risk indicators such as LVEF and GFR, which further supports the role of TMAO as an important biomarker for HF assessment and management. The retrieved evidence implies that interventions aiming to alter gut microbiota and reduce TMAO could have the potential to help patients with HF.

    Keywords: TMAO, Heart Failure, gut microbiome, metabolite, chronic heart failure

    Received: 30 May 2024; Accepted: 13 Sep 2024.

    Copyright: © 2024 Jarmukhanov, Mukhanbetzhanov, Kozhakhmetov, Nurgaziyev, Sailybayeva, Bekbossynova and Kushugulova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zharkyn Jarmukhanov, Laboratory of Microbiome, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan

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