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REVIEW article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1435720
This article is part of the Research Topic New Insights in Prosthetic Joint Infections View all 7 articles

Antibiotics with antibiofilm activity -Rifampicin and beyond

Provisionally accepted
Luís Ferreira Luís Ferreira Ema Pos Ema Pos *Daniela R. Nogueira Daniela R. Nogueira *Filipa P. Ferreira Filipa P. Ferreira *Ricardo Sousa Ricardo Sousa Miguel A. Abreu Miguel A. Abreu *
  • Hospital de Santo António, Porto, Portugal

The final, formatted version of the article will be published soon.

    The management of prosthetic joint infections is a complex and multilayered process that is additionally complicated by the formation of bacterial biofilm. Foreign material provides the ideal grounds for the development of an intricate matrix that hinders treatment and creates a difficult environment for antibiotics to act. Surgical intervention is often warranted but requires appropriate adjunctive therapy. Despite available guidelines, several aspects of antibiotic therapy with antibiofilm activity lack clear definition. Given the escalating challenges posed by antimicrobial resistance, extended treatment durations, and tolerance issues, it is essential to ensure that antimicrobials with antibiofilm activity are both potent and diverse. Evidence of biofilm-active drugs is highlighted, and alternatives to classical regimens are further discussed.

    Keywords: Prosthetic joint infection, Biofilm, Antibiofilm activity, Antibiotic therapy, biofilm active antibiotics, Drug Resistance

    Received: 20 May 2024; Accepted: 07 Aug 2024.

    Copyright: © 2024 Ferreira, Pos, Nogueira, Ferreira, Sousa and Abreu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ema Pos, Hospital de Santo António, Porto, Portugal
    Daniela R. Nogueira, Hospital de Santo António, Porto, Portugal
    Filipa P. Ferreira, Hospital de Santo António, Porto, Portugal
    Miguel A. Abreu, Hospital de Santo António, Porto, Portugal

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