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REVIEW article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1431785
This article is part of the Research Topic Acute/chronic pathogen infections: Roles of resident, probiotic, and live biotherapeutic microbes in limiting or preventing disease View all 23 articles

Oral microbiota and metabolites: key players in oral health and disorder, and Microbiotabased therapies

Provisionally accepted
Narjess Bostanghadiri Narjess Bostanghadiri 1Mobina Kouhzad Mobina Kouhzad 2Elahe Taki Elahe Taki 3Zahra Elahi Zahra Elahi 1Amin Khoshbayan Amin Khoshbayan 1Davood Darban-Sarokhalil Davood Darban-Sarokhalil 1*Tahereh Navidifar Tahereh Navidifar 4*
  • 1 Iran University of Medical Sciences, Tehran, Iran
  • 2 Department of Molecular Biology and Genetics, Faculty of Science, İzmir Institute of Technology, Urla, Izmir, Türkiye
  • 3 Kermanshah University of Medical Sciences, Kermanshah, Kerman, Iran
  • 4 Shushtar School of Medical Sciences, Shoushtar, Khuzestan, Iran

The final, formatted version of the article will be published soon.

    The review aimed to investigate the diversity of oral microbiota and its influencing factors, as well as the association of oral microbiota with oral health and the possible effects of dysbiosis and oral disorder. The oral cavity harbors a substantial microbial burden, which is particularly notable compared to other organs within the human body. In usual situations, the microbiota exists in a state of equilibrium; however, when this balance is disturbed, a multitude of complications arise.Dental caries, a prevalent issue in the oral cavity, is primarily caused by the colonization and activity of bacteria, particularly streptococci. Furthermore, this environment also houses other pathogenic bacteria that are associated with the onset of gingival, periapical, and periodontal diseases, as well as oral cancer. Various strategies have been employed to prevent, control, and treat these disorders. Recently, techniques utilizing microbiota, like probiotics, microbiota transplantation, and the replacement of oral pathogens, have caught the eye. This extensive examination seeks to offer a general view of the oral microbiota and their metabolites concerning oral health and disease, and also the resilience of the microbiota, and the techniques used for the prevention, control, and treatment of disorders in this specific area.

    Keywords: Oral microbiota, Bacteria, Periodontal disease, oral cavity, Microbiota metabolites

    Received: 14 May 2024; Accepted: 02 Aug 2024.

    Copyright: © 2024 Bostanghadiri, Kouhzad, Taki, Elahi, Khoshbayan, Darban-Sarokhalil and Navidifar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Davood Darban-Sarokhalil, Iran University of Medical Sciences, Tehran, Iran
    Tahereh Navidifar, Shushtar School of Medical Sciences, Shoushtar, Khuzestan, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.