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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1429360
This article is part of the Research Topic Rodent model organisms: Therapeutic treatments and drugs interaction with the gut microbiome View all 32 articles

Effect of Gegen-qinlian Decoction on regulation of gut microbiota and metabolites in type II diabetic rats

Provisionally accepted
Jinyao Xu Jinyao Xu 1Zhenkai Zou Zhenkai Zou 1Xuanyi Li Xuanyi Li 1Xiangjun Sun Xiangjun Sun 2Xufeng Wang Xufeng Wang 2Feng Qin Feng Qin 2Abulikemu Abulizi Abulikemu Abulizi 2Qian Chen Qian Chen 2Zhigang Pan Zhigang Pan 2Hexiao Shen Hexiao Shen 3Yongling Lv Yongling Lv 3Ruicheng Yan Ruicheng Yan 1,4*
  • 1 The First Clinical Medical School, Hubei University of Chinese Medicine, Hubei, China
  • 2 Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei Province, China
  • 3 Maintainbiotech. Ltd. (Wuhan), Wuhan, Hebei Province, China
  • 4 Hubei University of Chinese Medicine, Wuhan, China

The final, formatted version of the article will be published soon.

    Gegen Qinlian Decoction (GGQLT) is a Chinese herbal medicine that has been reported to have a significant therapeutic effect in type II diabetes mellitus (T2DM). In this study, we constructed a T2DM rat model by feeding high-fat diet and injecting streptozotocin (STZ), and tested the effects of feeding GGQLT and fecal transplantation on the physiological indexes, microbiota and metabolism of rats. Results showed that the administration of GGQLT can significantly improve the growth performance of rats and has a remarkable antihyperlipidemic effect. In addition, GGQLT altered the composition of gut microbiota by increasing beneficial bacteria such as Coprococcus, Bifidobacterium, Blautia, and Akkermansia.Additionally, GGQLT elevated levels of specific bile acids by metabolomics analysis, potentially contributing to improvements in lipid metabolism. These findings suggest that GGQLT may have beneficial effects on T2DM by influencing lipid metabolism and gut microbiota. However, further studies are needed to elucidate its mechanisms and assess clinical applications.

    Keywords: Type II diabetes mellitus (T2DM), Gegen Qinlian Decoction (GGQLT), fecal microbiome transplant (FMT), Traditional Chinese medicine (TCM), Gut Microbiota, Metabolites

    Received: 09 May 2024; Accepted: 12 Jul 2024.

    Copyright: © 2024 Xu, Zou, Li, Sun, Wang, Qin, Abulizi, Chen, Pan, Shen, Lv and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ruicheng Yan, The First Clinical Medical School, Hubei University of Chinese Medicine, Hubei, 430065, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.