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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Systems Microbiology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1426807

Causal roles of skin microbiota in skin cancers suggested by genetic study

Provisionally accepted
Yuhang Zhu Yuhang Zhu 1Liu Wanguo Liu Wanguo 1Mei Wang Mei Wang 2Xu Wang Xu Wang 1Sibo Wang Sibo Wang 2*
  • 1 China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China
  • 2 First Affiliated Hospital of Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Novelty and Impact: Previous MR analyses have focused on exploring the impact of gut microbiota on a multitude of diseases, but research on skin microbiota is still scarce. This is the first Mendelian randomization to report the causal association between skin microbiota and skin cancers. We identified 294 skin microbiota based on phylum, class, order, family, genus, and ASV level information from the first GWAS study across three skin microenvironments. This MR analysis revealed that the skin microbiota was bidirectionally causally associated with skin cancers, and had the potential to provide early diagnosis, preventive measures, and additional therapeutic options for skin cancers.

    Keywords: Skin microbiota, Skin Cancer, Mendelian randomization, Genetics, causal inference

    Received: 03 May 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Zhu, Wanguo, Wang, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sibo Wang, First Affiliated Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.