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REVIEW article

Front. Microbiol.
Sec. Virology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1423044

An effective pan-serotype dengue vaccine and enhanced control strategies could help in reducing the severe dengue burden in Bangladesh–A perspective

Provisionally accepted
Mohammad Enamul Hoque Kayesh Mohammad Enamul Hoque Kayesh 1*Humayra Nazneen Humayra Nazneen 2Michinori Kohara Michinori Kohara 3Kyoko Tsukiyama-Kohara Kyoko Tsukiyama-Kohara 4*
  • 1 Patuakhali Science and Technology University, Patuakhali, Chittagong, Bangladesh
  • 2 Dhaka Medical College and Hospital, Dhaka, Dhaka, Bangladesh
  • 3 Tokyo Metropolitan Institute of Medical Science, Tokyo, Tôkyô, Japan
  • 4 Kagoshima University, Kagoshima, Japan

The final, formatted version of the article will be published soon.

    Dengue is an important vector-borne disease occurring globally. Dengue virus (DENV) infection can result in a potentially life-threatening disease. To date, no DENV-specific antiviral treatment is available. Moreover, an equally effective pan-serotype dengue virus vaccine is not available. Recently, two DENV vaccines, Dengvaxia and Qdenga, were licensed for limited use. However, none of them have been approved in Bangladesh. DENV is transmitted by Aedes mosquitoes, and global warming caused by climate change favoring Aedes breeding plays an important role in increasing DENV infections in Bangladesh. Dengue is a serious public health concern in Bangladesh. In the year 2023, Bangladesh witnessed its largest dengue outbreak, with the highest number of dengue cases (n=321,179) and dengue-related deaths (n=1,705) in a single epidemic year. There is an increased risk of severe dengue in individuals with preexisting DENV-specific immunoglobulin G if the individuals become infected with different DENV serotypes. To date, vector control has remained the mainstay for controlling dengue; therefore, an immediate, strengthened, and effective vector control program is critical and should be regularly performed for controlling dengue outbreaks in Bangladesh. In addition, the use of DENV vaccine in curbing dengue epidemics in Bangladesh requires more consideration and judgement by the respective authority of Bangladesh. This review provides perspectives on the control and prevention of dengue outbreaks. We also discuss the challenges of DENV vaccine use to reduce dengue epidemics infection in Bangladesh.

    Keywords: Dengue Virus, dengue virus vaccine, Severe dengue fever, epidemic, Bangladesh

    Received: 25 Apr 2024; Accepted: 06 Aug 2024.

    Copyright: © 2024 Kayesh, Nazneen, Kohara and Tsukiyama-Kohara. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Mohammad Enamul Hoque Kayesh, Patuakhali Science and Technology University, Patuakhali, 1209, Chittagong, Bangladesh
    Kyoko Tsukiyama-Kohara, Kagoshima University, Kagoshima, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.