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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1420872
This article is part of the Research Topic Rodent model organisms: Therapeutic treatments and drugs interaction with the gut microbiome View all 37 articles

Alleviating effect of Lactobacillus rhamnosus SDSP202418 on exerciseinduced fatigue in mice

Provisionally accepted
Yang Yang Yang Yang 1Yuanji Zhao Yuanji Zhao 2*Huan Lei Huan Lei 1
  • 1 Chengdu Sport University, Chengdu, Sichuan Province, China
  • 2 Wuhan Sports University, Wuhan, China

The final, formatted version of the article will be published soon.

    In this study, the effects of Lactobacillus rhamnosus SDSP202418 isolated from shrimp paste on the exercise performance of fatigued mice were analyzed, and the potential action mechanism was revealed. L. rhamnosus SDSP202418 significantly improved the exhaustion time of the mice and regulated the biochemical indices (lactate dehydrogenase, nitrogen, uric acid) of the fatigued mice to resist fatigue. L. rhamnosus SDSP202418 also upregulated the mRNA expression of slow muscle fibers and downregulated the mRNA expression of fast muscle fibers in the exercise mice by activating the AMPK/PGC-1α pathway in the fatigued mice. It also increased the contents of antioxidant enzymes (superoxide dismutase, catalase, and glutathione) in the liver and muscle. These enzymes removed and repaired oxidative free radicals to achieve antifatigue. In addition, L. rhamnosus SDSP202418 can change the gut microbial structure and modulate the abundance and balance of fatigue-related gut microbiota, which in turn exerts anti-fatigue effects. L. rhamnosus SDSP202418 is a functional food component that can effectively relieve fatigue after exercise.

    Keywords: Probiotics, Lactobacillus rhamnosus SDSP202418, Antifatigue, Oxidative Stress, Muscle fiber, intestinal flora

    Received: 21 Apr 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Yang, Zhao and Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuanji Zhao, Wuhan Sports University, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.