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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1419424
This article is part of the Research Topic The Gut-Liver Axis: the Main Role of Microbiome in Liver Diseases View all 13 articles

Candida tropicalis ZD-3 prevents excessive fat deposition by regulating ileal microbiota and bile acids enterohepatic circulation in broilers

Provisionally accepted
Jiaqi Feng Jiaqi Feng Fang Wang Fang Wang Shanshan Nan Shanshan Nan Lijing Dou Lijing Dou Xiaotong Pang Xiaotong Pang Jun-li Niu Jun-li Niu Wenju Zhang Wenju Zhang Cunxi Nie Cunxi Nie *
  • Shihezi University, Shihezi, China

The final, formatted version of the article will be published soon.

    Evidence suggests that the dietary intake of Candida tropicalis ZD-3 (ZD-3) has various health benefits, but the treatment mechanisms and effects remain unclear. The aim of this study investigates the effect of ZD-3 on reducing fat deposition in broilers and the underlying mechanism. 180 one-dayold, yellow-feathered broilers were randomly divided into three groups: control (CON) group fed a basal diet, an active Candida tropicalis ZD-3 (ZD) group supplemented with ZD, and a heatinactivated Candida tropicalis ZD-3 (HZD) group supplemented with HZD. The experiment lasted for 28 d. The ZD and HZD treatments significantly reduced the abdominal fat index (P < 0.05), decreased TG levels in serum and liver (P < 0.05), altered the ileal microbial composition by reducing the Firmicutes to Bacteroidetes (F/B) ratio. Additionally, the ZD and HZD treatments reduced liver cholesterol by decreasing ileal FXR-FGF19 signaling and increasing liver FXR-SHP signaling (P < 0.05). The ZD and HZD treatments also changed liver PC and TG classes lipid composition, regulating liver lipid metabolism by promoting TG degradation and modulating the signal transduction of the cell membrane. Overall, ZD-3 was effective in improving lipid metabolism in broilers by regulating the ileal microbial composition and BAs enterohepatic circulation. This study provides a theoretical basis for the development and application of ZD-3 for the regulation of lipid metabolism in broilers.

    Keywords: Candida tropicalis ZD-3, Gut Microbiota, Bile acid metabolism, Lipid Metabolism, Yellow-feathered broiler

    Received: 22 Apr 2024; Accepted: 02 Aug 2024.

    Copyright: © 2024 Feng, Wang, Nan, Dou, Pang, Niu, Zhang and Nie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Cunxi Nie, Shihezi University, Shihezi, China

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