AUTHOR=Zhang Meiqi , Han Zhongyu , Lin Yumeng , Jin Zi , Zhou Shuwei , Wang Siyu , Tang Yuping , Li Jiaxuan , Li Xueping , Chen Haoran 

TITLE=Understanding the relationship between HCV infection and progression of kidney disease

JOURNAL=Frontiers in Microbiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1418301

DOI=10.3389/fmicb.2024.1418301

ISSN=1664-302X

ABSTRACT=<p>Hepatitis C virus (HCV) can cause a range of kidney diseases. HCV is the primary cause of mixed cryoglobulinaemia, which leads to cryoglobulinaemic vasculitis and cryoglobulinaemic glomerulonephritis (GN). Patients with acute cryoglobulinaemic vasculitis often exhibit acute kidney disease due to HCV infection, which typically progresses to acute kidney injury (AKI). HCV also increases the risk of chronic kidney disease (CKD) and the likelihood of developing end-stage renal disease (ESRD). Currently, direct-acting antiviral agents (DAAs) can be used to treat kidney disease at different stages. This review focuses on key findings regarding HCV and kidney disease, discusses the impact of DAAs, and highlights the need for further research and treatment.</p>