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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Systems Microbiology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1417904

Causal Relationship Between Gut Microbiota and Gynecological Tumor:A Two-Sample Mendelian Randomization Study

Provisionally accepted
Yajun Xiong Yajun Xiong *Xiaonan Zhang Xiaonan Zhang Xiaoya Niu Xiaoya Niu Long Zhang Long Zhang Yanbing Sheng Yanbing Sheng Aiguo Xu Aiguo Xu
  • First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    The causality between gut microbiota and gynecologic tumors remains unclear. This study employs Mendelian randomization (MR) to identify specific pathogenic bacterial communities associated with gynecologic tumors. We used data from the MiBioGen consortium on gut microbiota as the exposure. Uterine fibroids (UF), endometrial cancer (EC), ovarian cancer (OC), and cervical cancer (CC) were selected as outcomes. We investigated the causal relationship between gut microbiota and gynecologic tumors, conducted sensitivity analyses, and validated our findings in an independent cohort. Additionally, reverse MR explored the potential for reverse causation. We found a reduced risk of UF associated with higher Lachnospiraceae (OR: 0.882, 95% CI: 0.793-0.999, P = 0.982). Conversely, increased Lachnospiraceae was linked to a higher incidence of OC (OR: 1.329, 95% CI: 1.019-1.732, P= 0.036). This study established a causal connection between Lachnospiraceae and both UF and OC, providing new insights into the role of gut microbiota in gynecological tumors.

    Keywords: Mendelian randomization, Gut Microbiota, Gynecological tumor, Uterine fibroids, ovarian cancer, Lachnospiraceae 2 growth, inhibiting pathogen colonization, and promoting epithelial regeneration. In summary

    Received: 26 Apr 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Xiong, Zhang, Niu, Zhang, Sheng and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yajun Xiong, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.