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MINI REVIEW article

Front. Microbiol.
Sec. Virology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1415417
This article is part of the Research Topic Neurotropic Virus Replication and Spread Within and Between Neurons View all 7 articles

Mechanisms of ferroptosis and the relationship between ferroptosis and ER stress after JEV and HSV infection

Provisionally accepted
Rui Zhou Rui Zhou Ke-Xin Wei Ke-Xin Wei Xin-Yu Li Xin-Yu Li Bei-Bei Yan Bei-Bei Yan Lin Li Lin Li *
  • Shanxi Medical University, Taiyuan, China

The final, formatted version of the article will be published soon.

    Ferroptosis is a novel form of programmed cell death, which is different from apoptosis, pyroptosis and autophagy in morphology and biochemistry. Ferroptosis is characterized by condensed mitochondrial membrane densities, vanished of mitochondria crista and outer membrane rupture in morphology, and the accumulation of intracellular iron, lipid peroxidation, decrease of GSH and inhibition of GPX4 in biochemistry. Japanese encephalitis virus (JEV) and Herpes simplex virus (HSV) are both common neurotropic viruses that can cause neurological disorders, such as severe encephalitis. JEV and HSV have been demonstrated to be able to induce ferroptosis. This process is closely related to the inhibition of the GSH-GPX4 system, ACSL4 phosphorylation, and Nrf2 ubiquitination. In this review, we summarized the mechanisms by which JEV and HSV induce ferroptosis in the current study. In addition, we found a strong relationship between endoplasmic reticulum stress and ferroptosis, and We therefore speculated that sustained ER stress might be a prerequisite for ferroptosis in JEV and HSV-induced diseases.

    Keywords: JEV, hsv, ferroptosis, LPO, ROS, er stress

    Received: 10 Apr 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Zhou, Wei, Li, Yan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lin Li, Shanxi Medical University, Taiyuan, China

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