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REVIEW article
Front. Microbiol.
Sec. Aquatic Microbiology
Volume 15 - 2024 |
doi: 10.3389/fmicb.2024.1413741
This article is part of the Research Topic Occurrence of Harmful Algal Blooms and Marine Biotoxins View all articles
Tetrodotoxin and the State-of-the-Art Progress of Its Associated Analytical Methods
Provisionally accepted- Binzhou Medical University, Binzhou, China
Tetrodotoxin (TTX), which is found in various marine organisms, including pufferfish, shellfish, shrimp, crab, marine gastropods, and gobies, is an effective marine toxin and the cause of many seafood poisoning incidents. Owing to its toxicity and threat to public health, the development of simple, rapid, and efficient analytical methods to detect TTX in various food matrices has garnered increasing interest worldwide. Herein, we reviewed the structure and properties, origin and sources, toxicity and poisoning, and relevant legislative measures of TTX. Additionally, we have mainly reviewed the state-of-the-art progress of analytical methods for TTX detection in the past five years, such as bioassays, immunoassays, instrumental analysis, and biosensors, and summarized their advantages and limitations. Furthermore, this review provides an in-depth discussion of the most advanced biosensors, including cell-based biosensors, immunosensors, and aptasensors. Overall, this study provides useful insights into the future development and wide application of biosensors for TTX detection.
Keywords: Tetrodotoxin, detection, Aptasensor, immunosensor, Cell biosensor
Received: 07 Apr 2024; Accepted: 12 Aug 2024.
Copyright: © 2024 Mi and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Sha Liu, Binzhou Medical University, Binzhou, China
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