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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1406350
This article is part of the Research Topic New Insights in Prosthetic Joint Infections View all 6 articles

In vitro evaluation of microbial D-and L-lactate production as biomarkers of infection

Provisionally accepted
Paula Morovic Paula Morovic Mercedes Gonzalez Moreno Mercedes Gonzalez Moreno Andrej Trampuz Andrej Trampuz Svetlana Karbysheva Svetlana Karbysheva *
  • Charité University Medicine Berlin, Berlin, Baden-Wurttemberg, Germany

The final, formatted version of the article will be published soon.

    Mammalian cells produce and metabolize almost exclusively L-lactate, bacterial species have the capacity to produce both D-lactate and L-lactate. The aim of this study was to evaluate the intrinsic production of D-and L-lactate in the most common pathogenic microorganisms causing septic arthritis (SA) and periprosthetic joint infection (PJI) as a potential biomarker for the diagnosis of infection. Following microorganisms were grown according to ATCC culture guides and tested for production of D-and L-lactate:

    Keywords: biomarker, Infection, D-lactate, Joint, Biofilm

    Received: 25 Mar 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Morovic, Gonzalez Moreno, Trampuz and Karbysheva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Svetlana Karbysheva, Charité University Medicine Berlin, Berlin, 10117, Baden-Wurttemberg, Germany

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.