AUTHOR=Liu Xueer , Chen Weiqiang , Li Kangsheng , Sheng Jiangtao 

TITLE=RNA N6-methyladenosine methylation in influenza A virus infection

JOURNAL=Frontiers in Microbiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1401997

DOI=10.3389/fmicb.2024.1401997

ISSN=1664-302X

ABSTRACT=<p>Influenza A virus (IAV) is a negative-sense single-stranded RNA virus that causes acute lung injury and acute respiratory distress syndrome, posing a serious threat to both animal and human health. N6-methyladenosine (m<sup>6</sup>A), a prevalent and abundant post-transcriptional methylation of RNA in eukaryotes, plays a crucial regulatory role in IAV infection by altering viral RNA and cellular transcripts to affect viral infection and the host immune response. This review focuses on the molecular mechanisms underlying m<sup>6</sup>A modification and its regulatory function in the context of IAV infection and the host immune response. This will provide a better understanding of virus–host interactions and offer insights into potential anti-IAV strategies.</p>