Que Chi Truong-Bolduc
Chun-Hsing Liao
Hidemasa Nakaminami
Jacob Strahilevitz
Leon G. Leanse- 1Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- 2School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan
- 3Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan
- 4Department of Clinical Microbiology and Infectious Diseases, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
- 5Health and Sport Sciences Hub, University of Gibraltar, Europa Point, Gibraltar
- 6Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
Editorial on the Research Topic
Microbial interactions and survival mechanisms in chronic respiratory infections
Chronic respiratory diseases (CRDs) such as cystic fibrosis (CF), non CF-bronchiectasis and asthma are common non-communicable diseases that affect the airways and other lung structures (Labaki and Han, 2020), and infections in CRD patients are caused by various pathogens (Cullen and McClean, 2015). Because of structural and functional dysfunctions of the lungs, patients are unable to clear the pathogens from the respiratory tract, thereby leading to the development of chronic phase of infections which are more difficult to treat by antibiotics. CRD patients might receive prolonged and repeated antibiotics, which hasten the evolution of bacteria.
Within a chronic infection site, the microbial community exercises various modalities of inter-species interactions resulting in a balance between competition and cooperation which ultimately leads to negative outcome for the patients (Limoli et al., 2016).
Cystic fibrosis (CF) is an autosomal recessively inherited disorder that affects major organs including the lungs. CF patients usually exhibit a thick mucus layer coating the airways that constitutes the habitat of many microbes including the two most common pathogens S. aureus and P. aeruginosa. Whereas early invading P. aeruginosa is known to secrete compounds that inhibit the growth of S. aureus, late P. aeruginosa strains, which exhibit less virulence, establish a coexistence with S. aureus (Pallett et al., 2019).
Camus et al. provide a review article on the subject of P. aeruginosa and S. aureus co-infection. They indicated that gene alterations and reduction of virulence factors via adjustment of specific regulators are some pathoadaptive changes that enhance the survival and persistence of P. aeruginosa at the infection site. These adaptive modifications lead to the emergence of more resistant to antibiotics but less virulent P. aeruginosa that show a reduced anti-staphylococcal activity, promoting a lifestyle of coexistence with S. aureus. Late S. aureus are frequently auxotrophic and survive as small colony variant (SCV) that are resistant to antibiotics and associated with worse respiratory complications in CF patients. The authors emphasize that S. aureus also influence the adaptation of P. aeruginosa to the CF environment and highlight the research gap in the long-term co-evolution of S. aureus and P. aeruginosa in CF patients and its impact on better infection management.
Various opportunistic microorganisms also colonize and infect the airways of CF patients, contributing to their morbidity and mortality (Cuthbertson et al., 2020). The frequent use of antibiotics affects both the targeted pathogens as well as the surrounding microbiota leading to alterations of the microbial community dynamics. CF patients are also treated with CFTR (CF transmembrane conductance regulator) modulators that adequately improve the pathophysiology and the CF environment to promote a healthy microbiota (Dawood et al., 2022; Miller et al., 2022; Sosinski et al., 2022). Understanding how multiple factors affect the microbiota of the CF airways is crucial in the attempt to manage the disease. Ho et al. developed a Lotka-Volterra model to analyze the ecological interactions between microbial taxa recorded in the UK CF registry during a period of 12 years (2008–2020). The authors report that certain medications appear to influence the “gut-lung axis” as well as the bacterial biofilm formation within the airway mucus which possibly impact the ecology of the CF airway. Furthermore, the authors suggest that CFTR modulators may also influence the gut physiology.
Non-CF bronchiectasis is a condition characterized by abnormal widened and inflamed lung airways that is associated with chronic cough, mucus production, and recurrent infections (McShane et al., 2013). The most common pathogen causing airway inflammation, exacerbation, leading to recurrent hospitalizations in non-CF bronchiectasis is P. aeruginosa, but other microbes, such as non-tuberculous mycobacteria (NTM) also play a role in these infections (Richardson et al., 2019). The implication of NTM is still unclear despite recent study indicating an association between NTM infection and patient body weight loss (Faverio et al., 2016). Lin et al. report on the impacts of NTM in non-CF bronchiectasis using a 16-year cohort study in Taiwan. The authors demonstrated that NTM in combination with P. aeruginosa or with fungi caused more exacerbations and respiratory failure in non-CF bronchiectasis patients. This is an important finding which requires further investigations.
Asthma is a common CRD that affects all age groups and is marked by inflammation of the bronchial tubes with sticky secretions insides the tubes. The pathogenesis of asthma is complex. Asthma is a chronic disease with significant economic impact due to long-term treatment (Kuruvilla et al., 2019). The comprehensive review by Galeana-Cadena et al. describes the roles of the microbiome in relation to the phenotypes and endotypes (mechanistic pathway leading to asthma) of asthma throughout human growth and development. The authors emphasize that the microbiome influences early-life immune development and modulation. They also point out the limitations of the studies conducted thus far which address these issues, due to difficulty obtaining relevant samples from certain areas of the human body. The authors express the needs to include virome and mycobiome in future studies investigating the mechanisms underlying these interactions.
Communications between host and microbiota involve components of the host immune system and bacterial antigens and exoproducts (Albillos et al., 2020). Xiao et al. provide a comprehensive review on the significance of bacterial membrane vesicles (MVs) as a communication vehicle between host and bacteria. The authors offer an analysis of the role of various classes of MVs in transport and immune response activation and raise the possibility of using MVs as a therapeutic approach, with applications in vaccines, in making adjuvant, or in designing a drug carrier.
Lastly, Yang et al. provide the evidence of a relationship between the quorum-sensing system and antibiotic resistance of P. aeruginosa. The authors demonstrate that clinical P. aeruginosa display phenotypic heterogeneity, and that P. aeruginosa isolates exhibiting broader antibiotic resistance also display a reduction in LasR-dependent extracellular proteases. These findings offer future strategies to address P. aeruginosa antibiotic resistance in CRDs.
In conclusion, the reviews and articles published in this Research Topic shed additional light on interactions between microbes infecting patients with CRDs and the bacterial mechanisms of adaptation to persist at the infection sites. The authors also provide insights into future development of therapeutic strategies and the importance of microbiome, mycobiome, and virome on human wellbeing.
Author contributions
QT-B: Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing. C-HL: Writing – review & editing. HN: Writing – review & editing. JS: Writing – review & editing. LL: Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Acknowledgments
All topic editors provided feedback on the editorial article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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Keywords: microbiome, interaction, survival, CRDs, bacteria, infections, antibiotics
Citation: Truong-Bolduc QC, Liao C-H, Nakaminami H, Strahilevitz J and Leanse LG (2024) Editorial: Microbial interactions and survival mechanisms in chronic respiratory infections. Front. Microbiol. 15:1387518. doi: 10.3389/fmicb.2024.1387518
Received: 17 February 2024; Accepted: 19 February 2024;
Published: 29 February 2024.
Edited and reviewed by: Axel Cloeckaert, Institut National de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), France
Copyright © 2024 Truong-Bolduc, Liao, Nakaminami, Strahilevitz and Leanse. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Que Chi Truong-Bolduc, qtruongbolduc@mgh.harvard.edu