AUTHOR=Luangphiphat Wongsakorn , Prombutara Pinidphon , Muangsillapasart Viroj , Sukitpunyaroj Damrong , Eeckhout Eric , Taweechotipatr Malai 

TITLE=Exploring of gut microbiota features in dyslipidemia and chronic coronary syndrome patients undergoing coronary angiography

JOURNAL=Frontiers in Microbiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1384146

DOI=10.3389/fmicb.2024.1384146

ISSN=1664-302X

ABSTRACT=<p>Chronic coronary syndrome (CCS) has a high mortality rate, and dyslipidemia is a major risk factor. Atherosclerosis, a cause of CCS, is influenced by gut microbiota dysbiosis and its metabolites. The objective of this study was to study the diversity and composition of gut microbiota and related clinical parameters among CCS patients undergoing coronary angiography and dyslipidemia patients in comparison to healthy volunteers in Thailand. CCS patients had more risk factors and higher inflammatory markers, high-sensitivity C-reactive protein (hs-CRP) than others. The alpha diversity was lower in dyslipidemia and CCS patients than in the healthy group. A significant difference in the composition of gut microbiota was observed among the three groups. The relative abundance of Proteobacteria, Fusobacteria, Enterobacteriaceae, <italic>Prevotella,</italic> and <italic>Streptococcus</italic> was significantly increased while <italic>Roseburia</italic>, <italic>Ruminococcus,</italic> and <italic>Faecalibacterium</italic> were lower in CCS patients. In CCS patients, Lachnospiraceae, Peptostreptococcaceae, and <italic>Pediococcus</italic> were positively correlated with hs-CRP. In dyslipidemia patients, <italic>Megasphaera</italic> was strongly positively correlated with triglyceride (TG) level and negatively correlated with high-density lipoprotein cholesterol (HDL-C). The modification of gut microbiota was associated with changes in clinical parameters involved in the development of coronary artery disease (CAD) in CCS patients.</p>