AUTHOR=Handa Vishal L. , Patel Bhoomi N. , Bhattacharya Dr. Arpita , Kothari Ramesh K. , Kavathia Dr. Ghanshyam , Vyas B. R. M. 

TITLE=A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital

JOURNAL=Frontiers in Microbiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1383989

DOI=10.3389/fmicb.2024.1383989

ISSN=1664-302X

ABSTRACT=<p>We investigated antibiotic resistance pattern in clinical bacterial pathogens isolated from in-patients and out-patients, and compared it with non-clinical bacterial isolates. 475 bacterial strains isolated from patients were examined for antibiotic resistance. <italic>Staphylococcus</italic> spp. (148; 31.1%) were found to be the most prevalent, followed by <italic>Klebsiella pneumoniae</italic> (135; 28.4%), <italic>Escherichia coli</italic> (74; 15.5%), <italic>Pseudomonas aeruginosa</italic> (65; 13.6%), <italic>Enterobacter</italic> spp. (28; 5.8%), and <italic>Acinetobacter</italic> spp. (25; 5.2%). Drug-resistant bacteria isolated were extended spectrum-β-lactamase <italic>K</italic>. <italic>pneumoniae</italic> (8.8%), <italic>E</italic>. <italic>coli</italic> (20%), metallo-β-lactamase <italic>P</italic>. <italic>aeruginosa</italic> (14; 2.9%), erythromycin-inducing clindamycin resistant (7.4%), and methicillin-resistant <italic>Staphylococcus</italic> species (21.6%). Pathogens belonging to the Enterobacteriaceae family were observed to undergo directional selection developing resistance against antibiotics ciprofloxacin, piperacillin-tazobactam, cefepime, and cefuroxime. Pathogens in the surgical ward exhibited higher levels of antibiotic resistance, while non-clinical <italic>P</italic>. <italic>aeruginosa</italic> and <italic>K</italic>. <italic>pneumoniae</italic> strains were more antibiotic-susceptible. Our research assisted in identifying the drugs that can be used to control infections caused by antimicrobial resistant bacteria in the population and in monitoring the prevalence of drug-resistant bacterial pathogens.</p>