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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1367740

Causal Relationship Between Gut Microbiota and Male Erectile Dysfunction: A Mendelian Randomization Analysis

Provisionally accepted
Shuaiqi Chen Shuaiqi Chen Guangyu Sun Guangyu Sun *Shangrong Wu Shangrong Wu Ranlu Liu Ranlu Liu *
  • Tianjin Medical University General Hospital, Tianjin, China

The final, formatted version of the article will be published soon.

    Several observational studies have reported an association between gut microbiota and male erectile dysfunction (ED). However, it remains unclear whether there is a causal relationship between gut microbiota and male ED. Thus, we aimed to investigate the potential causal relationship between gut microbiota and male ED through Mendelian randomization (MR) analysis.To assess the causal relationship between gut microbiota and male ED, we performed a two-sample MR analysis.We obtained gut microbiota genome-wide association studies (GWAS) data from the MiBioGen consortium and publicly available GWAS data on male ED from the OPEN GWAS database. Subsequently, we performed a two-sample MR analysis to evaluate the causal relationship between gut

    Keywords: Gut Microbiota, Erectile Dysfunction, Mendelian randomization, GWAS, causal relationship

    Received: 22 Jan 2024; Accepted: 15 Aug 2024.

    Copyright: © 2024 Chen, Sun, Wu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Guangyu Sun, Tianjin Medical University General Hospital, Tianjin, 300052, China
    Ranlu Liu, Tianjin Medical University General Hospital, Tianjin, 300052, China

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