AUTHOR=Huang Xiaomei , Wang Yichao , Li Guangyu , Shao Zongze , Xia Jinmei , Qin Jiang-Jiang , Wang Weiyi 

TITLE=Secondary metabolites from the deep-sea derived fungus Aspergillus terreus MCCC M28183

JOURNAL=Frontiers in Microbiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1361550

DOI=10.3389/fmicb.2024.1361550

ISSN=1664-302X

ABSTRACT=<p><italic>Aspergillus</italic> fungi are renowned for producing a diverse range of natural products with promising biological activities. These include lovastatin, itaconic acid, terrin, and geodin, known for their cholesterol-regulating, anti-inflammatory, antitumor, and antibiotic properties. In our current study, we isolated three dimeric nitrophenyl trans-epoxyamides (<bold>1</bold>–<bold>3</bold>), along with fifteen known compounds (<bold>4</bold>–<bold>18</bold>), from the culture of <italic>Aspergillus terreus</italic> MCCC M28183, a deep-sea-derived fungus. The structures of compounds <bold>1</bold>–<bold>3</bold> were elucidated using a combination of NMR, MS, NMR calculation, and ECD calculation. Compound <bold>1</bold> exhibited moderate inhibitory activity against human gastric cancer cells MKN28, while compound <bold>7</bold> showed similar activity against MGC803 cells, with both showing IC<sub>50</sub> values below 10 μM. Furthermore, compound <bold>16</bold> exhibited moderate potency against <italic>Vibrio parahaemolyticus</italic> ATCC 17802, with a minimum inhibitory concentration (MIC) value of 7.8 μg/mL. This promising research suggests potential avenues for developing new pharmaceuticals, particularly in targeting specific cancer cell lines and combating bacterial infections, leveraging the unique properties of these <italic>Aspergillus</italic>-derived compounds.</p>