AUTHOR=Cai Jin , Zhou Xueming , Wang Bin , Zhang Xuelong , Luo Mengyao , Huang Longtao , Wang Ruoxi , Chen Yonghao , Li Xiaoyang , Luo Youping , Chen Guangying , Cao Fei , Huang Guolei , Zheng Caijuan 

TITLE=Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35

JOURNAL=Frontiers in Microbiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1342843

DOI=10.3389/fmicb.2024.1342843

ISSN=1664-302X

ABSTRACT=<p>Six new polyketides, which includes three new lactones (talarotones A–C) <bold>(1–3)</bold>, one new polyketide (talarotide A) <bold>(4)</bold>, two new polyenes (talaroyenes A, B) <bold>(5, 6)</bold>, together with one new meroterpenoid (talaropenoid A) <bold>(7)</bold> and 13 known compounds <bold>(8–20)</bold> were isolated from the mangrove-derived fungus <italic>Talaromyces flavus</italic> TGGP35. The structure and configuration of the compounds <bold>1</bold>–<bold>7</bold> were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo<sub>2</sub> (OAc)<sub>4</sub>-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds <bold>5</bold> and <bold>20</bold> displayed antioxidant activity with IC<sub>50</sub> values of 0.40 and 1.36 mM, respectively. Compounds <bold>3</bold>, <bold>6</bold>, <bold>11</bold>, <bold>16</bold>, and <bold>17</bold> displayed cytotoxic activity against human cancer cells Hela, A549, and had IC<sub>50</sub> values ranging from 28.89 to 62.23 μM. Compounds <bold>7</bold>, <bold>10</bold>–<bold>12</bold>, and <bold>14</bold>–<bold>18</bold> exhibited moderate or potent anti-insect activity against newly hatched larvae of <italic>Helicoverpa armigera</italic> Hubner, with IC<sub>50</sub> values in the range 50–200 μg/mL. Compound <bold>18</bold> showed antibacterial activity against <italic>Ralstonia solanacearum</italic> with the MIC value of 50 μg/mL.</p>