AUTHOR=Wang Yuquan , Su Wenya , Liu Zhiqiang , Wang Yihua , Li Ling , Xu Hai , Wang Mingyu , Shen Wenlong 

TITLE=The microbiomic signature of hemorrhoids and comparison with associated microbiomes

JOURNAL=Frontiers in Microbiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1329976

DOI=10.3389/fmicb.2024.1329976

ISSN=1664-302X

ABSTRACT=<p>Hemorrhoids are a common ailment that can cause significant disruptions to one’s daily life. While some researchers have speculated about a potential link between hemorrhoid development and gut microbes, there is currently insufficient evidence to support this claim. In this study, we collected samples from 60 hemorrhoid patients and analyzed the composition and characteristics of microbiomes in hemorrhoids. PCoA results revealed distinct differences between the microbiomes of hemorrhoids, skin-originated microbiomes, and gut microbes, highlighting the complex nature of hemorrhoidal microbiomes. The distribution characteristics of <italic>Staphylococcus</italic> suggest that the skin microbiome influences the microbiome of hemorrhoids. Additionally, we observed higher levels of <italic>Prevotella</italic> in two cases of thrombosed hemorrhoids compared to non-thrombosed hemorrhoids. This finding suggests that <italic>Prevotella</italic> may play a crucial role in the development of thrombosed hemorrhoids.</p>