AUTHOR=Yamasaki Seiji , Yoneda Tomohiro , Ikawa Sota , Hayashi-Nishino Mitsuko , Nishino Kunihiko 

TITLE=Investigating multidrug efflux pumps associated with fatty acid salt resistance in Escherichia coli

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.954304

DOI=10.3389/fmicb.2023.954304

ISSN=1664-302X

ABSTRACT=<p>Fatty acids salts exert bactericidal and bacteriostatic effects that inhibit bacterial growth and survival. However, bacteria can overcome these effects and adapt to their environment. Bacterial efflux systems are associated with resistance to different toxic compounds. Here, several bacterial efflux systems were examined to determine their influence on fatty acid salt resistance in <italic>Escherichia coli.</italic> Both <italic>acrAB</italic> and <italic>tolC E. coli</italic> deletion strains were susceptible to fatty acid salts, while plasmids carrying <italic>acrAB</italic>, <italic>acrEF</italic>, <italic>mdtABC</italic>, or <italic>emrAB</italic> conferred drug resistance to the Δ<italic>acrAB</italic> mutant, which indicated complementary roles for these multidrug efflux pumps. Our data exemplify the importance of bacterial efflux systems in <italic>E. coli</italic> resistance to fatty acid salts.</p>