Yu-Ting Tang
Wei-Qi He- Jiangsu Key Laboratory of Neuropsychiatric Diseases and Cambridge-Suda (CAM-SU) Genomic Resource Center, Medical College of Soochow University, Suzhou, Jiangsu, China
Editorial on the Research Topic
Insights in microorganisms in vertebrate digestive systems: 2022
The entire microbiota of the digestive tract, spanning from the oral cavity to the rectum, is established through interactions with the external environment, a process initiated during the fetal stage (Martino et al., 2022). Microorganisms intricately influence host physiological activities (Westermann and Vogel, 2021), engaging with the nervous system, immune system, and various organs (Morais et al., 2021; Tilg et al., 2022). Imbalances in the microecology impact diverse aspects of the host's cognition, emotions, diet, and metabolism (Fan and Pedersen, 2021). Deyaert et al. established an in vitro dynamic ileal microbiota model to investigate bacterial activity. Additionally, Pan et al. highlighted the regulatory role of flavonoids in shaping the human gut microbiota structure. We underscore that an understanding of microbial ecology can unveil the host's health status. This Research Topic aims to provide a comprehensive overview of cutting-edge studies on the symbiotic relationship between microorganisms and digestive system. This aligns with the summaries provided by Liang et al., Kasarello et al., and White et al. contributing insights and addressing current challenges in the exploration of microorganism interactions across multiple systems.
The gut microbiota actively participates in the human physiological and pathological activities (Shalon et al., 2023). Its potential as prognosis indicators or treatment targets has been deeply explored. Hu et al. illustrated the microbial landscape of the gallbladder in patients with gallstones, revealing significant alterations in bacterial taxonomic composition and strengthened correlation between bacterial and fungal communities in bile, potentially linked to gallstone formation. Xiang et al. connected the saliva microbiota changes with the renal function recovery in renal transplant patients during the perioperative period, suggesting them as biomarkers for postoperative recovery. Jiao et al. reported that a rising abundance of Actinobacteria and Bifidobacterium in the intestine following salidroside treatment, correlated with downregulation of Tomm7 (translocase of outer mitochondrial membrane 7) in the hippocampus, ameliorating memory impairment after long-term ethanol intake in rats. Zhao M. et al. proposed that an increase in Shigella and a decrease in Prevotella and Bacteroides may contribute to the occurrence and development of myasthenia gravis. The imbalance of the microbial community can be adjusted by Modified Buzhong Yiqi Decoction treatment, further enhancing host immune function.
Beyond its implications for human diseases, the gut microbiota holds the potential for developments in animal husbandry. Ji et al. proposed that organic Mn supplementation in the diet had more advantages than the sulfate forms in weaning calves, maintaining a more stable microbial community. Zhao W. et al. demonstrated that a diet supplemented with glucose oxidase may strengthen the immunologic barrier and maintain a healthy intestinal microecology. A deeper understanding of the microbiota community aids in optimizing gut function and improving feeding efficiency. Zhang et al. documented dynamic changes in fecal microbiota in donkey foals during weaning, while He et al. manipulated gut microbial and metabolic profiles through hybridization in Tunchang pigs. Regarding microbial structure, composition, and functional capacity as crucial assessment, Li et al. disclosed that house ammonia exposure in rabbits may impact on local immune responses and inflammatory processes. Liu et al. disclosed a higher prevalence of multidrug-resistant Proteus mirabilis in domestic dogs, along with corresponding antibiotic resistance genes. This finding emphasizes the importance of prudent antibiotic management by veterinarians. The study of vertebrate microbiota offers an opportunity to comprehensively monitor the health status of livestock, ensuring the high-quality of husbandry products (Wen et al., 2021).
It is inspiring that our Research Topic has garnered attention from researchers worldwide, including those from the USA, Poland, Belgium, the Netherlands, and China. We extend our gratitude to all authors who contributed their original work to this Research Topic and the reviewers for their invaluable comments. We also express our sincere thanks to the editorial office of Frontiers in Microbiology for their excellent support and for providing us with the opportunity to successfully host this hot topic issue.
Author contributions
Y-TT: Writing—original draft, Writing—review & editing. W-QH: Funding acquisition, Writing—original draft, Writing—review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (31971062), the Open Fund of National Facility for Translational Medicine (Shanghai) (TMSK-2021-301), and the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (20KJA180003).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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References
Fan, Y., and Pedersen, O. (2021). Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71. doi: 10.1038/s41579-020-0433-9
Martino, C., Dilmore, A. H., Burcham, Z. M., Metcalf, J. L., Jeste, D., and Knight, R. (2022). Microbiota succession throughout life from the cradle to the grave. Nat. Rev. Microbiol. 20, 707–720. doi: 10.1038/s41579-022-00768-z
Morais, L. H., Schreiber, H. L., and Mazmanian, S. K. (2021). The gut microbiota-brain axis in behaviour and brain disorders. Nat. Rev. Microbiol. 19, 241–255. doi: 10.1038/s41579-020-00460-0
Shalon, D., Culver, R. N., Grembi, J. A., Folz, J., Treit, P. V., Shi, H., et al. (2023). Profiling the human intestinal environment under physiological conditions. Nature. 617, 581–591. doi: 10.1038/s41586-023-05989-7
Tilg, H., Adolph, T. E., and Trauner, M. (2022). Gut-liver axis: Pathophysiological concepts and clinical implications. Cell Metab. 34, 1700–1718. doi: 10.1016/j.cmet.2022.09.017
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., et al. (2021). Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens. Microbiome. 9, 126. doi: 10.1186/s40168-021-01040-x
Keywords: gut microbiota, human diseases, animal husbandry, microbial imbalances, physiological impact
Citation: Tang Y-T and He W-Q (2024) Editorial: Insights in microorganisms in vertebrate digestive systems: 2022. Front. Microbiol. 14:1344969. doi: 10.3389/fmicb.2023.1344969
Received: 27 November 2023; Accepted: 18 December 2023;
Published: 05 January 2024.
Edited and reviewed by: Knut Rudi, Norwegian University of Life Sciences, Norway
Copyright © 2024 Tang and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Wei-Qi He, d2hlJiN4MDAwNDA7c3VkYS5lZHUuY24=