AUTHOR=Wang Wenxue , Liu Zhongjian , Zhang Yu , Guo Zhiping , Liu Jieyu , Li Siyun , Huang Jihua , Geng Jiawei , Zhang Fan , Guo Qiang 

TITLE=Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1288920

DOI=10.3389/fmicb.2023.1288920

ISSN=1664-302X

ABSTRACT=<p>The effects of <italic>Helicobacter pylori</italic> eradication on gastric mucosa-colonizing microbes in patients with functional dyspepsia (FD) remain unclear. Here, we explored microbial variation induced by <italic>H. pylori</italic> infection and eradication treatment in FD patients. Gastric microbial abundance and diversity were significantly reduced in the <italic>H. pylori</italic>-infected FD patients. Eradication treatment increased alpha and beta diversity of gastric mucosa-colonizing microbes, and promoted the expansion of several probiotic microbes, such as <italic>Leuconostoc mesenteroides</italic>, which exhibited a matched antagonistic performance against <italic>H. pylori</italic>. Significant variation was observed in gastric mucosa-colonizing microbes between <italic>H. pylori</italic>-positive and <italic>H. pylori</italic>-negative FD patients. Eradication treatment induced microbial diversity recovery and may provide sufficient nutrition and space for probiotic microbes, such as <italic>Leuconostoc mesenteroides</italic>.</p>