AUTHOR=Zhu Lanlan , Li Ping , Zhang Guangyi , He Zhiyong , Tao Xingyu , Ji Yicheng , Yang Wenjing , Zhu Xiaofang , Luo Wanying , Liao Wenjian , Chen Chuanhui , Liu Yang , Zhang Wei 

TITLE=Role of the ISKpn element in mediating mgrB gene mutations in ST11 hypervirulent colistin-resistant Klebsiella pneumoniae

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1277320

DOI=10.3389/fmicb.2023.1277320

ISSN=1664-302X

ABSTRACT=Colistin has emerged as a last-resort therapeutic against antibiotic-resistant bacterial infections, particularly those attributed to carbapenem-resistant Enterobacteriaceae (CRE) like CRKP. Yet, alarmingly, approximately 45% of multidrug-resistant Klebsiella pneumoniae strains now manifest resistance to colistin. Through our study, we discerned that the synergy between carbapenemase and IS elements amplifies resistance in Klebsiella pneumoniae, thereby narrowing the existing therapeutic avenues.