AUTHOR=Ignatyeva Olga , Tolyneva Darya , Kovalyov Aleksandr , Matkava Lorena , Terekhov Mikhail , Kashtanova Daria , Zagainova Anzhelika , Ivanov Mikhail , Yudin Vladimir , Makarov Valentin , Keskinov Anton , Kraevoy Sergey , Yudin Sergey 

TITLE=Christensenella minuta, a new candidate next-generation probiotic: current evidence and future trajectories

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1241259

DOI=10.3389/fmicb.2023.1241259

ISSN=1664-302X

ABSTRACT=<sec id="sec1"><title>Background</title><p>As the field of probiotic research continues to expand, new beneficial strains are being discovered. The <italic>Christensenellaceae</italic> family and its newly described member, <italic>Christensenella minuta</italic>, have been shown to offer great health benefits. We aimed to extensively review the existing literature on these microorganisms to highlight the advantages of their use as probiotics and address some of the most challenging aspects of their commercial production and potential solutions.</p></sec><sec id="sec2"><title>Methods</title><p>We applied a simple search algorithm using the key words “<italic>Christensenellaceae</italic>” and “<italic>Christensenella minuta</italic>” to find all articles reporting the biotherapeutic effects of these microorganisms. Only articles reporting evidence-based results were reviewed.</p></sec><sec id="sec3"><title>Results</title><p>The review showed that <italic>Christensenella minuta</italic> has demonstrated numerous beneficial properties and a wider range of uses than previously thought. Moreover, it has been shown to be oxygen-tolerant, which is an immense advantage in the manufacturing and production of <italic>Christensenella minuta</italic>-based biotherapeutics. The results suggest that <italic>Christensenellaceae</italic> and <italic>Christensenella munita</italic> specifically can play a crucial role in maintaining a healthy gut microbiome. Furthermore, <italic>Christensenellaceae</italic> have been associated with weight management. Preliminary studies suggest that this probiotic strain could have a positive impact on metabolic disorders like diabetes and obesity, as well as inflammatory bowel disease.</p></sec><sec id="sec4"><title>Conclusion</title><p><italic>Christensenellaceae</italic> and <italic>Christensenella munita</italic> specifically offer immense health benefits and could be used in the management and therapy of a wide range of health conditions. In addition to the impressive biotherapeutic effect, <italic>Christensenella munita</italic> is oxygen-tolerant, which facilitates commercial production and storage.</p></sec>