AUTHOR=Alvarado-Peña Néstor , Galeana-Cadena David , Gómez-García Itzel Alejandra , Mainero Xavier Soberón , Silva-Herzog Eugenia 

TITLE=The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1237998

DOI=10.3389/fmicb.2023.1237998

ISSN=1664-302X

ABSTRACT=<p>Tuberculosis is a chronic infectious disease caused by <italic>Mycobacterium tuberculosis</italic> (MTB) that remains a significant global health challenge. The extensive use of antibiotics in tuberculosis treatment, disrupts the delicate balance of the microbiota in various organs, including the gastrointestinal and respiratory systems. This gut-lung axis involves dynamic interactions among immune cells, microbiota, and signaling molecules from both organs. The alterations of the microbiome resulting from anti-TB treatment can significantly influence the course of tuberculosis, impacting aspects such as complete healing, reinfection, and relapse. This review aims to provide a comprehensive understanding of the gut-lung axis in the context of tuberculosis, with a specific focus on the impact of anti-TB treatment on the microbiome.</p>