AUTHOR=Ferreira Beatriz L. , Ferreira Dionisia P. , Borges Swanny F. , Ferreira Adriana M. , Holanda Fabricio H. , Ucella-Filho João G. M. , Cruz Rodrigo Alves S. , Birolli Willian G. , Luque Rafael , Ferreira Irlon M. TITLE=Diclofenac, ibuprofen, and paracetamol biodegradation: overconsumed non-steroidal anti-inflammatories drugs at COVID-19 pandemic JOURNAL=Frontiers in Microbiology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1207664 DOI=10.3389/fmicb.2023.1207664 ISSN=1664-302X ABSTRACT=
The consumption of non-steroidal anti-inflammatory drugs (NSAIDs) have increased significantly in the last years (2020–2022), especially for patients in COVID-19 treatment. NSAIDs such as diclofenac, ibuprofen, and paracetamol are often available without restrictions, being employed without medical supervision for basic symptoms of inflammatory processes. Furthermore, these compounds are increasingly present in nature constituting complex mixtures discarded at domestic and hospital sewage/wastewater. Therefore, this review emphasizes the biodegradation of diclofenac, ibuprofen, and paracetamol by pure cultures or consortia of fungi and bacteria at