AUTHOR=Wang Zhenhui , Li Zhanlin , Niu Chao , Yang Lanping , Zhai Yangyang , Li Dehai , Wu Guangwei , Zhang Zhenzhen , He Xueqian 

TITLE=Aniline-induced production of aniline-containing polyketides and related bicyclic polyketides by the Yellow River wetland-derived fungus Talaromyces funiculosus

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1200680

DOI=10.3389/fmicb.2023.1200680

ISSN=1664-302X

ABSTRACT=<sec><title>Introduction and Methods</title><p>Silencing gene activation can effectively enrich the diversity of fungal secondary metabolites.</p></sec><sec><title>Results and Discussion</title><p>Cultivation of the Yellow River wetland-derived fungus <italic>Talaromyces funiculosus</italic> HPU-Y01 with aniline led to the isolation of one new aniline-containing polyketide tanicutone A (<bold>1</bold>), two new bicyclic polyketides tanicutones B-C (<bold>2</bold>–<bold>3</bold>), a new related trienoic acid 8-methyldeca-2,4,6-trienoic acid (<bold>5</bold>), and a known compound <bold>4</bold>. The planar structures and configurations of <bold>1</bold>–<bold>5</bold> were determined by NMR, MS, and ECD calculations. Compound <bold>2</bold> featured a key aldehyde group and showed promising inhibitory activity against <italic>Vibrio parahaemolyticus</italic> with a minimum inhibitory concentration (MIC) value of 0.17 μg/mL. This is a rare report of aniline-induced fungal production of tetrahydronaphthone polyketides.</p></sec>