AUTHOR=Li Jinjie , Yang Ge , Zhang Qihe , Liu Zhuo , Jiang Xin , Xin Ying 

TITLE=Function of Akkermansia muciniphila in type 2 diabetes and related diseases

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1172400

DOI=10.3389/fmicb.2023.1172400

ISSN=1664-302X

ABSTRACT=<p>The prevalence of type 2 diabetes (T2D) is increasing worldwide, with many patients developing long-term complications that affect their cardiovascular, urinary, alimentary, and other systems. A growing body of literature has reported the crucial role of gut microbiota in metabolic diseases, one of which, <italic>Akkermansia muciniphila,</italic> is considered the “next-generation probiotic” for alleviating metabolic disorders and the inflammatory response. Although extensive research has been conducted on <italic>A. muciniphila</italic>, none has summarized its regulation in T2D. Hence, this review provides an overview of the effects and multifaceted mechanisms of <italic>A. muciniphila</italic> on T2D and related diseases, including improving metabolism, alleviating inflammation, enhancing intestinal barrier function, and maintaining microbiota homeostasis. Furthermore, this review summarizes dietary strategies for increasing intestinal <italic>A. muciniphila</italic> abundance and effective gastrointestinal delivery.</p>